ArticleMetabolic brain disease2018
Protective effects of Scutellaria baicalensis Georgi extract on D-galactose induced aging rats.
Article in Metabolic brain disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Multi-omics uncovers the critical role of ceramide-mediatedJournal of pharmaceutical analysis · 2026Article
- Research progress on pharmacological properties and application of probiotics in the fermentation ofFrontiers in nutrition · 2024Review
- Article
- A Systematic Review of In Vivo Studies of the Efficacy of Herbal Medicines for Anti-Aging in the Last Five Years.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Effect of DietaryAnimals : an open access journal from MDPI · 2022Article
- Pinocembrin attenuates hemorrhagic transformation after delayed t-PA treatment in thromboembolic stroke rats by regulating endogenous metabolites.Acta pharmacologica Sinica · 2021Article
- Applications, phytochemistry, pharmacological effects, pharmacokinetics, toxicity ofChinese medicine · 2020Review
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Authors and funding
7 authors.
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Abstract
Scutellaria baicalensis Georgi (SBG), a traditional Chinese herb, has attracted considerable attention for its wide range of pharmacological activities. This study aimed to investigate the intervention effects of SBG ethanol extract on aging rats induced by D-galactose (D-gal) and to explore potential mechanisms by serum and liver metabolic profiles. The aging rats were induced by the D-gal (100 mg/kg) for 10 weeks continuously with subcutaneous injection, while the control rats received physiological saline. Two other groups of rats were administered with 100 mg/kg/day and 200 mg/kg/day of SBG by oral route following D-gal injections. The abilities of spatial and learning memory were evaluated by open-field test and Morris water maze test. Then, some biochemical indexes related to cognitive ability and aging were measured. Histopathological feature in hippocampal region was observed by Hematoxylin and eosin (HE) staining. The changes of metabolic profiles were evaluated using proton nuclear magnetic resonance (
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