ArticleIndian journal of gastroenterology : official journal of the Indian Society of Gastroenterology2018
Genotyping of hepatitis B virus isolates from Lahaul and Spiti district in Himachal Pradesh, India.
Article in Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- A Recent Prevalence of Hepatitis B Virus (HBV) Genotypes and Subtypes in Asia: A Systematic Review and Meta-Analysis.Healthcare (Basel, Switzerland) · 2023Review
- Identification of hepatitis B virus genotypes detected in Lahaul & Spiti district of Himachal Pradesh, India.The Indian journal of medical research · 2022Article
- Hepatitis B genotyping: The utility for the clinicians.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2020Article
- Serological markers and molecular analysis of hepatitis B infection in a tertiary care hospital at Kathmandu, Nepal.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2020Article
- Seroprevalence and risk factors of hepatitis B virus infection in tribal population of Himalayan district Lahaul and Spiti, India.Pathogens and global health · 2019Article
- Hepatitis B in Trans-Himalayan Tribal Population: High Prevalence, High Pediatric Burden, Virologic Patterns, and Implications for Public Health Interventions.Journal of clinical and experimental hepatologyArticle
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Abstract
Hepatitis B virus (HBV) has several genotypes. In the Indian population, genotypes A and D are the most frequent. HBV infection is hyper-endemic in the Lahaul and Spiti district in Himachal Pradesh; however, the virus genotype in this area is not known. We sequenced a 398-nucleotide segment of HBV genome that included parts of pre-S1/S2 and polymerase genes from 17 specimens from this district, and assigned a viral genotype to these. Of the 17 specimens studied, 13 (76% [95% confidence interval = 50-92%]) showed the presence of genotype C HBV; the remaining four were genotype D (n = 4; 24%) HBV. Prevalence of genotype C HBV was much higher in the district than in other parts of India. This may reflect the historical mixing of this population with that in China. Since genotype C has a higher risk of chronicity and mother-to-child transmission, prevention of HBV infection may need particular emphasis in this area.
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