Evidence map›Paper›PMID 29855843›Full record

ArticleMolecular imaging and biology2019

The Value of In Vitro Binding as Predictor of In Vivo Results: A Case for [

Graham B Cole, Nagichettiar Satyamurthy, Jie Liu, Koon-Pong Wong, Gary W Small, Sung-Cheng Huang, Janez Košmrlj, Jorge R Barrio, Andrej Petrič

Abstract readComparative StudyEvaluation Study
PubMed Publisher
In one paragraph

Article in Molecular imaging and biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. [International psychogeriatrics · 2021
    Trial
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Graham B ColeDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, CHS B2-086A, 694817, 10833 Le Conte Avenue, Los Angeles, CA, 90095-6948, USA.
Nagichettiar SatyamurthyDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, CHS B2-086A, 694817, 10833 Le Conte Avenue, Los Angeles, CA, 90095-6948, USA.
Jie LiuDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, CHS B2-086A, 694817, 10833 Le Conte Avenue, Los Angeles, CA, 90095-6948, USA.
Koon-Pong WongDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, CHS B2-086A, 694817, 10833 Le Conte Avenue, Los Angeles, CA, 90095-6948, USA.
Gary W SmallDepartment of Psychiatry and Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, UCLA Longevity Center, David Geffen School of Medicine at the University of California, Los Angeles, CA, 90024, USA.
Sung-Cheng HuangDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, CHS B2-086A, 694817, 10833 Le Conte Avenue, Los Angeles, CA, 90095-6948, USA.
Janez KošmrljFaculty of Chemistry and Chemical Technology, University of Ljubljana, Večna pot 113, SI-1000, Ljubljana, Slovenia.
Jorge R BarrioDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, CHS B2-086A, 694817, 10833 Le Conte Avenue, Los Angeles, CA, 90095-6948, USA. jbarrio@mednet.ucla.edu.
Andrej PetričFaculty of Chemistry and Chemical Technology, University of Ljubljana, Večna pot 113, SI-1000, Ljubljana, Slovenia. andrej.petric@fkkt.uni-lj.si.ORCID http://orcid.org/0000-0001-5294-9902
University of California, Los Angeles · USUniversity of Ljubljana · SI

Funding

VISUALIZING BRAIN A-BETA, TAU /SEROTONIN RECEPTOR DENSITP01AG025831 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SMALL, GARY WILLIAM · 2005 to 2010
$7.0M
NIA NIH HHS P01 AG025831
6 · The paper itself

Abstract

purposeCaution is warranted when in vitro results of biomarkers labeled with tritium were perfunctorily used to criticize in vivo data and conclusions derived with the same tracers labeled with positron emitters and positron emission tomography (PET). This concept is illustrated herein with the PET utilization of [ PROCEDURE: The present work describes full details on the synthesis, characterization, purity, and kinetics of radiolytic stability of [

resultsThe autoradiographic results using phosphate buffered saline (PBS) with less than 1 % EtOH and pure, freshly prepared [

conclusionsThis work illustrates the sensitivity of in vitro techniques to various experimental conditions and underscores that conclusions obtained from translational in vitro to in vivo determinations must always be performed with extreme care to avoid wrong interpretations that can be perpetuated and assumed without further analysis.

Indexed as

AutoradiographyBrainDiagnosisDrug StabilityFluorodeoxyglucose F18FormaldehydeHumansImmunohistochemistryIn Vitro TechniquesMicrotomyNitrilesPositron-Emission TomographyPredictive Value of TestsPrognosisProtein BindingRadiopharmaceuticals2-(1-(6-((2-fluoroethyl)(methyl)amino)-2-naphthyl)ethylidene)malononitrileFluorodeoxyglucose F18FormaldehydeNitrilesRadiopharmaceuticals[18F]FDDNP[3H]FDDNP[3H]FENEAutoradiographyAutoradiolysisKinetics

Identifiers

PMID29855843
OpenAlexW2807100542

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.