SynthesisAnnals of surgical oncology2018
Impact of Extent of Surgery on Tumor Recurrence and Survival for Papillary Thyroid Cancer Patients.
Synthesis in Annals of surgical oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- 2025 American Thyroid Association Management Guidelines for Adult Patients with Differentiated Thyroid Cancer.Thyroid : official journal of the American Thyroid Association · 2025Guideline
- Total thyroidectomy versus lobectomy for papillary thyroid cancer: A systematic review and meta-analysis.Medicine · 2020Pooled it
- Systematic Review of Recurrence Rate after Hemithyroidectomy for Low-Risk Well-Differentiated Thyroid Cancer.European thyroid journal · 2020Pooled it
- Independent Prognostic Value ofCancers · 2026Review
- Preoperative and Intraoperative Assessment of Extrathyroidal Extension in Unilateral Papillary Thyroid Carcinoma: Does It Necessitate Total Thyroidectomy?Journal of surgical oncology · 2026Article
- Comparable long-term survival outcomes after lobectomy versus total thyroidectomy treatment of minimal extrathyroidal extension differentiated thyroid cancer patients.Gland surgery · 2026Article
- Association of patient health education with the postoperative health related quality of life in low- intermediate recurrence risk differentiated thyroid cancer patients.Scientific reports · 2026Article
- Identification of oxidative stress-related genes in papillary thyroid carcinoma and their common targets with resveratrol based on bioinformatics, network pharmacology, and molecular docking.Discover oncology · 2025Article
- [Update on papillary thyroid cancer-What is relevant for surgeons?]Chirurgie (Heidelberg, Germany) · 2025Article
- Impact of fellowship training for specialists on thyroidectomy outcomes of patients with thyroid cancer.Scientific reports · 2024Review
- Article
- Racial and Ethnic Disparities in Appropriate Thyroid Cancer Treatment, Before and After the Release of the 2015 American Thyroid Association Guidelines.Annals of surgical oncology · 2023Article
- The relative importance of treatment outcomes to surgeons' recommendations for low-risk thyroid cancer.Surgery · 2023Article
- Continuing controversies on the extent of surgery in papillary thyroid carcinoma.Gland surgery · 2023Article
- Survey of Korean head and neck surgeons and endocrinologists for the surgical extent of 1.5 and 2.5 cm papillary thyroid carcinoma.Gland surgery · 2022Article
- Clinicopathological and surgical comparisons of differentiated thyroid cancer between China and the USA: A multicentered hospital-based study.Frontiers in public health · 2022Article
- Patient-reported outcomes following total thyroidectomy and lobectomy in thyroid cancer survivors: an analysis of the PROFILES Registry data.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Article
- A Prognostic Model of Differentiated Thyroid Cancer Based on Up-Regulated Glycolysis-Related Genes.Frontiers in endocrinology · 2022Article
- Thyroid Lobectomy for Low-Risk Papillary Thyroid Cancer: A National Survey of Low- and High-Volume Surgeons.Annals of surgical oncology · 2021Article
- Patients' Reaction to Diagnosis with Thyroid Cancer or an Indeterminate Thyroid Nodule.Thyroid : official journal of the American Thyroid Association · 2021Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe extent of surgery for low-risk papillary thyroid cancer (PTC) has been the subject of debate among experts for decades.
objectiveIn this paper, we aimed to systematically review whether thyroid lobectomy versus total thyroidectomy for PTC patients with tumors measuring 1.0-4.0 cm impacts tumor recurrence and survival.
resultsA systematic review of the literature from January 1990 to February 2018 yielded 13 relevant studies, including eight national cancer registry database studies, one multi-institutional thyroid cancer-specific database, three large-scale institutional series, and one meta-analysis. Data from these studies demonstrate that total thyroidectomy for the treatment of PTC measuring 1.0-4.0 cm does not confer a clinically significant improvement in disease-specific survival compared with thyroid lobectomy. Four of six studies also reported that total thyroidectomy is associated with a small but statistically significant improvement in disease-free survival, although it is argued whether this difference is clinically significant.
conclusionsWhile the quality of the data limit the strength of our conclusions, and while tumor characteristics, patient risk factors, and preferences should be considered, most data support that lobectomy and total thyroidectomy yield comparable oncologic outcomes for PTC measuring 1.0-4.0 cm.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.