ArticleLangenbeck's archives of surgery2018
Predictors of lymph node metastasis in patients with gastrointestinal stromal tumors (GISTs).
Article in Langenbeck's archives of surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
- Transanal endoscopic microsurgery (TEM) for rectal GI stromal tumour.Surgical endoscopy · 2026Article
- Is lymph node metastasis an advanced event of gastrointestinal stromal tumor?The oncologist · 2025Article
- Clinical characteristics of gastrointestinal stromal tumors with lymph node metastasis: a retrospective single-center study.Future oncology (London, England) · 2025Article
- Predictive models of lymph node metastasis in patients with gastrointestinal stromal tumors based on machine learning algorithms: a SEER-based retrospective study.Journal of gastrointestinal oncology · 2025Article
- Two Cases of Succinate Dehydrogenase-Deficient Juvenile Gastric Gastrointestinal Stromal Tumor.Surgical case reports · 2025Article
- The influence of lymphadenectomy on the prognosis of small intestinal stromal tumors: a study based on the SEER database.Surgical endoscopy · 2024Article
- Automated machine learning for predicting liver metastasis in patients with gastrointestinal stromal tumor: a SEER-based analysis.Scientific reports · 2024Article
- Article
- Effects of surgical management for gastrointestinal stromal tumor patients with liver metastasis on survival outcomes.Frontiers in oncology · 2024Article
- Lymph Node Metastases in Gastrointestinal Stromal Tumors: an Uncommon Event.Annals of surgical oncology · 2022Article
- Survival outcome of local vs. radical excision in rectal gastrointestinal stromal tumor: a SEER database analysis.BMC surgery · 2022Article
- Combined model based on enhanced CT texture features in liver metastasis prediction of high-risk gastrointestinal stromal tumors.Abdominal radiology (New York) · 2022Article
- A novel nomogram for predicting liver metastasis in patients with gastrointestinal stromal tumor: a SEER-based study.BMC surgery · 2020Article
- Gastrointestinal stromal tumors (GIST): a proposal of a "CT-based predictive model of Miettinen index" in predicting the risk of malignancy.Abdominal radiology (New York) · 2020Article
- Long-term survival among patients with gastrointestinal stromal tumors diagnosed after another malignancy: a SEER population-based study.World journal of surgical oncology · 2020Article
- [Clinicopathological features and prognosis of colorectal stromal tumor].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2020Article
- Establishment and Verification of Synchronous Metastatic Nomogram for Gastrointestinal Stromal Tumors (GISTs): A Population-Based Analysis.Gastroenterology research and practice · 2020Article
- Lymphadenectomy is associated with poor survival in patients with gastrointestinal stromal tumors.Annals of translational medicine · 2019Article
- Simple Scoring Model Based on Enhanced CT in Preoperative Prediction of Biological Risk of Gastrointestinal Stromal Tumor.Technology in cancer research & treatmentArticle
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLymph node metastasis is not common among patients with gastrointestinal stromal tumors (GISTs) and its prognostic value is controversial. The purposes of this study are to identify predictors of lymph node metastasis and determine its prognostic associations.
methodsA retrospective analysis of the surveillance, epidemiology and end results (SEER) database was performed. Patients with GISTs that underwent surgery and pathologic nodal staging were identified. Logistic regression and Cox regression were performed to identify independent predictors and prognostic factors, respectively.
resultsOf 1430 patients (age: 61.5 ± 14.5 years, 52% males), 140 (9.8%) had lymph node metastasis. On multivariable analysis, distant metastasis was the only independent predictor of lymph node metastasis (OR 4.95, 95% CI: 2.43-10.08, p < 0.001). In the entire cohort, lymph node metastasis did not reflect a worse overall survival (OS, HR 1.12, 95% CI: 0.49-2.58, p = 0.794) or disease-specific survival (DSS, HR 0.95, 95% CI: 0.31-2.88, p = 0.924), but was an independent predictor of worse OS in 51 patients (25.4% of 201 patients) who presented with both lymph node metastasis and synchronous distant metastasis (HR 2, 95% CI: 1.25-3.21, p = 0.004). Lymph node metastasis was also independently associated with worse survival among patients with small intestinal (OS: HR 1.88, 95% CI: 1.15-3.1, p = 0.013) and colorectal tumors (OS: HR 3.41, 95% CI: 1.56-7.46, p = 0.002, DSS: HR 3.58, 95% CI: 1.27-10.06, p = 0.016).
conclusionsMetastatic disease is an independent predictor of lymph node metastasis in patients with GISTs. Lymph node metastasis is also associated with worse overall survival in patients with metastatic GISTs.
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