ArticleDocumenta ophthalmologica. Advances in ophthalmology2018
ISCEV extended protocol for the photopic negative response (PhNR) of the full-field electroretinogram.
Article in Documenta ophthalmologica. Advances in ophthalmology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07748715 (Blue Color Processing in the Eye as a Biomarker of Brain Dopamine), which is not on this map. Cited by 130 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Blue Color Processing in the Eye as a Biomarker of Brain Dopamine
Who cites it
130 citing papers in PubMed, 2 syntheses or guidelines pooled it, 175 citations in OpenAlex.
- ISCEV and IPS guideline for the full-field stimulus test (FST).Documenta ophthalmologica. Advances in ophthalmology · 2024Guideline
- VEP estimation of visual acuity: a systematic review.Documenta ophthalmologica. Advances in ophthalmology · 2021Pooled it
- Retinal GABAergic Alterations in Adults with Autism Spectrum Disorder.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Trial
- Correlation between OCT-angiography and photopic negative response in patients with primary open angle glaucoma.International ophthalmology · 2023Trial
- The rapid N-wave as a potentially useful measure of the photopic negative response.Documenta ophthalmologica. Advances in ophthalmology · 2020Trial
- Measuring electroretinograms in tree shrews with a portable electrophysiology device.Documenta ophthalmologica. Advances in ophthalmology · 2026Article
- Photopic negative response (PhNR) of the full-field electroretinogram as a biomarker of retinal ganglion cell loss in glaucoma: a systematic review and meta-analysis.Documenta ophthalmologica. Advances in ophthalmology · 2026Article
- Preoperative structural and electrophysiological markers associated with visual outcome after idiopathic epiretinal membrane surgery.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Mitochondrial Homeostasis Mediates the Sustained Neuroprotection of CNTF-Chitosan Hydrogel Against NMDA-Induced Retinal Ganglion Cell Excitotoxicity.International journal of molecular sciences · 2026Article
- Structure-function relationship between handheld photopic negative response and macular GCIPL thickness in chronic optic neuropathy.Documenta ophthalmologica. Advances in ophthalmology · 2026Article
- Improving Parkinson's disease diagnosis by non-invasive detection of retinal biomarkers in MPTP monkeys using ERG and pupillometry.NPJ Parkinson's disease · 2026Article
- Dose-Response Characteristics of Retinal Inactivation Due to Intravitreal Injections of Tetrodotoxin in Nonhuman Primates.Investigative ophthalmology & visual science · 2026Article
- The area under the waveform as an alternative measure of the photopic negative response.Documenta ophthalmologica. Advances in ophthalmology · 2026Article
- The luminance-response function of the photopic negative response (PhNR): analysing different stimulation, recording and measurement approaches.Documenta ophthalmologica. Advances in ophthalmology · 2026Article
- Functional and structural retinal alterations in Alzheimer's disease: insights from photopic negative response (PhNR) and OCT-based analysis.Documenta ophthalmologica. Advances in ophthalmology · 2026Article
- Applications of Photopic Negative Response: A Narrative Review.Journal of clinical medicine · 2026Review
- The 5-HT1A receptor antagonist WAY-100635 maleate promotes retinal ganglion cell differentiation and protects the retino-visual circuits.Communications medicine · 2026Article
- ISCEV extended protocol for the photoreceptor directed ERG using full-field silent substitution stimuli.Documenta ophthalmologica. Advances in ophthalmology · 2026Review
- Retinal electrophysiological responses to dopaminergic therapy in treatment naïve Parkinson's disease.Documenta ophthalmologica. Advances in ophthalmology · 2026Article
- The mesopic negative response (MeNR): a novel approach to assess retinal ganglion cell function within the rod pathway.Documenta ophthalmologica. Advances in ophthalmology · 2025Article
70 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 7 institutions in 4 countries.
Funding
Abstract
The International Society for Clinical Electrophysiology of Vision (ISCEV) Standard for full-field electroretinography (ERG) describes a minimum procedure, but encourages more extensive testing. This ISCEV extended protocol describes an extension to the ERG Standard, namely the photopic negative response (PhNR) of the light-adapted flash ERG, as a well-established technique that is broadly accepted by experts in the field. The PhNR is a slow negative-going wave after the b-wave that provides information about the function of retinal ganglion cells and their axons. The PhNR can be reduced in disorders that affect the innermost retina, including glaucoma and other forms of optic neuropathy. This document, based on existing literature, provides a protocol for recording and analyzing the PhNR in response to a brief flash. The protocol includes full-field stimulation, a frequency bandwidth of the recording in which the lower limit does not exceed 0.3 Hz, and a spectrally narrowband stimulus, specifically, a red flash on a rod saturating blue background. Suggested flash strengths cover a range up to and including the minimum required to elicit a maximum amplitude PhNR. This extended protocol for recording the PhNR provides a simple test of generalized retinal ganglion cell function that could be added to standard ERG testing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.