Evidence map›Paper›PMID 29855729›Full record

ArticleEJNMMI research2018

Evaluation of hepatic integrin αvβ3 expression in non-alcoholic steatohepatitis (NASH) model mouse by

Takemi Rokugawa, Haruyo Konishi, Miwa Ito, Hitoshi Iimori, Ryohei Nagai, Eku Shimosegawa, Jun Hatazawa, Kohji Abe

Open access · goldAbstract read
In one paragraph

Article in EJNMMI research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 25 citations in OpenAlex.

  1. Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
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  10. Evaluation of an Integrin αNuclear medicine and molecular imaging · 2023
    Article
  11. Targeting integrin pathways: mechanisms and advances in therapy.Signal transduction and targeted therapy · 2023
    Review
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Takemi RokugawaTranslational Research Unit, Biomarker R&D Department, Shionogi & Co., Ltd., 3-1-1, Futaba-cho, Toyonaka, Osaka, 561-0825, Japan. takemi.rokugawa@shionogi.co.jp.ORCID http://orcid.org/0000-0003-2320-3145
Haruyo KonishiObesity and Metabolic Diseases, Drug Discovery and Disease Research Laboratory, Shionogi & Co., Ltd., Osaka, Japan.
Miwa ItoTranslational Research Unit, Biomarker R&D Department, Shionogi & Co., Ltd., 3-1-1, Futaba-cho, Toyonaka, Osaka, 561-0825, Japan.
Hitoshi IimoriDepartment of Applied Chemistry and Analysis, Research Laboratory for Development, Shionogi & Co., Ltd., Osaka, Japan.
Ryohei NagaiObesity and Metabolic Diseases, Drug Discovery and Disease Research Laboratory, Shionogi & Co., Ltd., Osaka, Japan.
Eku ShimosegawaDepartment of Molecular Imaging in Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
Jun HatazawaDepartment of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, Osaka, Japan.
Kohji AbeTranslational Research Unit, Biomarker R&D Department, Shionogi & Co., Ltd., 3-1-1, Futaba-cho, Toyonaka, Osaka, 561-0825, Japan.
Shionogi (Japan) · JPThe University of Osaka · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundActivated hepatic stellate cells (HSCs), which express integrin αvβ3, are a major fibrogenic factor in NASH pathophysiology.

resultsThirty-two male C57BL/6 mice aged 6 weeks were fed a choline-deficient, L-amino acid-defined, high-fat diet (CDAHFD) for 3 and 8 weeks.

conclusionsThe hepatic uptake of

Indexed as

18F-FPP-RGD2FibrosisHigh-fat dietIntegrin αvβ3Modified methionine choline-deficientNon-alcoholic fatty liver diseaseNon-alcoholic steatohepatitisPositron emission tomography

Identifiers

PMID29855729
PMCPMC5981157
OpenAlexW2806415489

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.