ReviewJournal of anesthesia2018
The history and progress of local anesthesia: multiple approaches to elongate the action.
Review in Journal of anesthesia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Clinical Studies on Topical Anesthesia in Dentistry: A Bibliometric Analysis.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Effect of low-level laser therapy on pain perception and anxiety levels in conventional local anesthesia injection.Journal of dental anesthesia and pain medicine · 2025Article
- An injectable controlled-release local anesthetic formulation of levobupivacaine based on a temperature-responsive polymer: Evaluation of analgesia, motor impairment, and histological toxicity in rats.Journal of anesthesia · 2025Article
- Advanced Hydrogel Systems for Local Anesthetic Delivery: Toward Prolonged and Targeted Pain Relief.Gels (Basel, Switzerland) · 2025Review
- Toward a solid microneedle patch for rapid and enhanced local analgesic action.Drug delivery and translational research · 2024Article
- The role of lidocaine in cancer progression and patient survival.Pharmacology & therapeutics · 2024Review
- Swiss paediatric dentists' preferences and experience on the use of articaine and other local/topical anaesthetics.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2024Article
- ProcClusterFrontiers in microbiology · 2024Article
- Intrathecal pramipexole and selegiline for sensory and motor block in rats.Pharmacological reports : PR · 2022Article
- Adverse effects following dental local anesthesia: a literature review.Journal of dental anesthesia and pain medicine · 2021Review
- Anesthetic efficacy of Gow-Gates versus inferior alveolar nerve block for irreversible pulpitis: a systematic quantitative review.Journal of dental anesthesia and pain medicine · 2021Review
- The Phospholipid Research Center: Current Research in Phospholipids and Their Use in Drug Delivery.Pharmaceutics · 2020Review
- Local anesthetic systemic toxicity: proposed mechanisms for lipid resuscitation and methods of prevention.Journal of anesthesia · 2019Article
- In reply: Use of low-molecular weight dextran as an LA adjuvant to extend LA action.Journal of anesthesia · 2019Article
- Adding dextran to local anesthetic enhances analgesia.Journal of anesthesia · 2019Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Analgesia and temporary inhibition of motor activity without interfering with central nervous function have been the essential merits of local anesthesia. Local anesthetics originated from cocaine have played a major role in local analgesia. However, the relatively short duration of action of local anesthetics has been a concern in intra- and post-operative analgesia. From the early age of modern local anesthesia, physicians and medical scientists had been struggling to control the active duration of local anesthetics. Such approach includes: development of long-acting local anesthetics, with physical tourniquet techniques, co-administration of other medicines such as vaso-constrictive agents or analgesics, development of mechanical devices to continuously or intermittently administer local anesthetics, and utilization of pharmaceutical drug delivery systems. In this review, the historical sequence of studies that have been performed in an effort to elongate the action of local anesthetics is presented, referring to epoch-making medical and scientific studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.