ArticleDiabetologia2018
An adult-based insulin resistance genetic risk score associates with insulin resistance, metabolic traits and altered fat distribution in Danish children and adolescents who are overweight or obese.
Article in Diabetologia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.
- Polygenic scores and physical fitness prediction: a systematic review.Human genetics · 2026Pooled it
- Genetic predisposition to higher body fat yet lower cardiometabolic risk in children and adolescents.International journal of obesity (2005) · 2019Pooled it
- Adult-based Genetic Risk Scores for Insulin Resistance Associate With Cardiometabolic Traits in Children and Adolescents.The Journal of clinical endocrinology and metabolism · 2025Article
- Article
- The Genetics of Type 2 Diabetes in Youth: Where We Are and the Road Ahead.The Journal of pediatrics · 2022Article
- Genetic Susceptibility to Insulin Resistance and Its Association with Estimated Longevity in the Hungarian General and Roma Populations.Biomedicines · 2022Article
- Relationship between glucose homeostasis and obesity in early life-a study of Italian children and adolescents.Human molecular genetics · 2022Article
- Genetic Risk Score for Type 2 Diabetes and Traits Related to Glucose-Insulin Homeostasis in Youth: The Exploring Perinatal Outcomes Among Children (EPOCH) Study.Diabetes care · 2021Article
- Genetic Risk Scores for Complex Disease Traits in Youth.Circulation. Genomic and precision medicine · 2020Article
- Article
- Interplay of an Obesity-Based Genetic Risk Score with Dietary and Endocrine Factors on Insulin Resistance.Nutrients · 2019Article
- Abdominal adiposity and cardiometabolic risk factors in children and adolescents: a Mendelian randomization analysis.The American journal of clinical nutrition · 2019Article
- Sphingolipids involved in T1DM.Nature reviews. Endocrinology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 7 institutions in 1 country.
Funding
Abstract
aims/hypothesisA genetic risk score (GRS) consisting of 53 insulin resistance variants (GRS
methodsWe examined a total of 689 children and adolescents who were overweight or obese and 675 children and adolescents from a population-based study. Anthropometric data, dual-energy x-ray absorptiometry scans, BP, fasting plasma glucose, fasting serum insulin and fasting plasma lipid measurements were obtained, and HOMA-IR was calculated. The GRS
resultsIn overweight/obese children and adolescents, the GRS CONCLUSIONS/
interpretationAn adult-based GRS comprising 53 insulin resistance susceptibility SNPs associates with insulin resistance, markers of the metabolic syndrome and altered fat distribution in a sample of Danish children and adolescents who were overweight or obese.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.