Evidence map›Paper›PMID 29855565›Full record

ArticleScientific reports2018

HDAC1 inhibition by MS-275 in mesothelial cells limits cellular invasion and promotes MMT reversal.

Lucia Rossi, Cecilia Battistelli, Valeria de Turris, Valeria Noce, Clemens Zwergel, Sergio Valente, Alessandra Moioli, Andrea Manzione, Marco Palladino, Veronica Bordoni and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

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  18. Next RNA Therapeutics: The Mine of Non-Coding.International journal of molecular sciences · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Lucia RossiDepartment of Cellular Biotechnologies and Hematology, Section of Molecular Genetics, Sapienza University of Rome, Rome, Italy.
Cecilia BattistelliDepartment of Cellular Biotechnologies and Hematology, Section of Molecular Genetics, Sapienza University of Rome, Rome, Italy.
Valeria de TurrisCenter for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Rome, Italy.ORCID 0000-0003-0872-185X
Valeria NoceDepartment of Cellular Biotechnologies and Hematology, Section of Molecular Genetics, Sapienza University of Rome, Rome, Italy.
Clemens ZwergelDepartment of Chemistry and Technologies of Drugs, Sapienza University of Rome, Rome, Italy.
Sergio ValenteDepartment of Chemistry and Technologies of Drugs, Sapienza University of Rome, Rome, Italy.
Alessandra MoioliDepartment of Clinical and Molecular Medicine, Sapienza University of Rome, Nephrology Unit, Sant'Andrea University Hospital, Rome, Italy.
Andrea ManzioneDepartment of Clinical and Molecular Medicine, Sapienza University of Rome, Nephrology Unit, Sant'Andrea University Hospital, Rome, Italy.
Marco PalladinoDepartment of Clinical and Molecular Medicine, Sapienza University of Rome, Nephrology Unit, Sant'Andrea University Hospital, Rome, Italy.
Veronica BordoniGene Expression Laboratory, National Institute for Infectious Diseases "Lazzaro Spallanzani" I.R.C.C.S., Rome, Italy.
Alessandro DomeniciDepartment of Clinical and Molecular Medicine, Sapienza University of Rome, Nephrology Unit, Sant'Andrea University Hospital, Rome, Italy.
Paolo MenèDepartment of Clinical and Molecular Medicine, Sapienza University of Rome, Nephrology Unit, Sant'Andrea University Hospital, Rome, Italy.
Antonello MaiDepartment of Chemistry and Technologies of Drugs, Sapienza University of Rome, Rome, Italy.ORCID 0000-0001-9176-2382
Marco TripodiDepartment of Cellular Biotechnologies and Hematology, Section of Molecular Genetics, Sapienza University of Rome, Rome, Italy. tripodi@bce.uniroma1.it.
Raffaele StrippoliDepartment of Cellular Biotechnologies and Hematology, Section of Molecular Genetics, Sapienza University of Rome, Rome, Italy. raffaele.strippoli@uniroma1.it.
Sapienza University of Rome · ITIstituto Nazionale per le Malattie Infettive Lazzaro Spallanzani · ITItalian Institute of Technology · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peritoneal fibrosis is a pathological alteration of the peritoneal membrane occurring in a variety of conditions including peritoneal dialysis (PD), post-surgery adhesions and peritoneal metastases. The acquisition of invasive and pro-fibrotic abilities by mesothelial cells (MCs) through induction of MMT, a cell-specific form of EMT, plays a main role in this process. Aim of this study was to evaluate possible effects of histone deacetylase (HDAC) inhibitors, key components of the epigenetic machinery, in counteracting MMT observed in MCs isolated from effluent of PD patients. HDAC inhibitors with different class/isoform selectivity have been used for pharmacological inhibition. While the effect of other inhibitors was limited to a partial E-cadherin re-expression, MS-275, a HDAC1-3 inhibitor, promoted: (i) downregulation of mesenchymal markers (MMP2, Col1A1, PAI-1, TGFβ1, TGFβRI) (ii) upregulation of epithelial markers (E-cadherin, Occludin), (iii) reacquisition of an epithelial-like morphology and (iv) marked reduction of cellular invasiveness. Results were confirmed by HDAC1 genetic silencing. Mechanistically, MS-275 causes: (i) increase of nuclear histone H3 acetylation (ii) rescue of the acetylation profile on E-cadherin promoter, (iii) Snail functional impairment. Overall, our study, pinpointing a role for HDAC1, revealed a new player in the regulation of peritoneal fibrosis, providing the rationale for future therapeutic opportunities.

Indexed as

AgedAged, 80 and overBenzamidesCadherinsCell MovementEpithelial CellsEpithelial-Mesenchymal TransitionFemaleHistone Deacetylase 1Histone Deacetylase InhibitorsHumansKidney Failure, ChronicMaleMiddle AgedPeritoneal DialysisPeritoneumBenzamidesCadherinsentinostatHDAC1 protein, humanHistone Deacetylase 1Histone Deacetylase InhibitorsPyridinesRNA, Small InterferingSNAI1 protein, humanSnail Family Transcription FactorsTransforming Growth Factor beta1

Identifiers

PMID29855565
PMCPMC5981641
OpenAlexW2807007249

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.