ArticleBMC biology2018
Dehydration triggers ecdysone-mediated recognition-protein priming and elevated anti-bacterial immune responses in Drosophila Malpighian tubule renal cells.
Article in BMC biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 53 citations in OpenAlex.
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- Dehydration Dynamics in Terrestrial Arthropods: From Water Sensing to Trophic Interactions.Annual review of entomology · 2023Review
- Lipids as a key element of insect defense systems.Frontiers in genetics · 2023Review
- Aedes aegypti Malpighian tubules are immunologically activated following systemic Toll activation.Parasites & vectors · 2022Article
- Vibrio cholerae high cell density quorum sensing activates the host intestinal innate immune response.Cell reports · 2022Article
- microRNA-252 and FoxO repress inflammaging by a dual inhibitory mechanism on Dawdle-mediated TGF-β pathway in Drosophila.Genetics · 2022Article
- Roles of peripheral clocks: lessons from the fly.FEBS letters · 2022Review
- Endocrine Regulation of Lifespan in Insect Diapause.Frontiers in physiology · 2022Review
- Ligand recognition by peptidoglycan recognition protein-S (PGRP-S): structure of the complex of camel PGRP-S with heptanoic acid at 2.15 Å resolution.International journal of biochemistry and molecular biology · 2022Article
- Microbiota-derived acetate activates intestinal innate immunity via the Tip60 histone acetyltransferase complex.Immunity · 2021Article
- The Impact of Age on Response to Infection inMicroorganisms · 2021Review
- Critical Roles of Spätzle5 in Antimicrobial Peptide Production AgainstFrontiers in immunology · 2021Article
- JNK signaling regulates oviposition in the malaria vector Anopheles gambiae.Scientific reports · 2020Article
- A putative UDP-glycosyltransferase from Heterorhabditis bacteriophora suppresses antimicrobial peptide gene expression and factors related to ecdysone signaling.Scientific reports · 2020Article
- Extracellular matrix induced by steroids and aging through a G-protein-coupled receptor in aDisease models & mechanisms · 2020Article
- Sugar-Induced Obesity and Insulin Resistance Are Uncoupled from Shortened Survival in Drosophila.Cell metabolism · 2020Article
- TmRelish is required for regulating the antimicrobial responses to Escherichia coli and Staphylococcus aureus in Tenebrio molitor.Scientific reports · 2020Article
- Significance of DopEcR, a G-protein coupled dopamine/ecdysteroid receptor, in physiological and behavioral response to stressors.Journal of neurogenetics · 2020Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundDrosophila is a powerful model for the study of factors modulating innate immunity. This study examines the effect of water-loss dehydration on innate immune responsiveness in the Drosophila renal system (Malpighian tubules; MTs), and how this leads to elevated host defense and contributes to immunosenescence.
resultsA short period of desiccation-elevated peptidoglycan recognition protein-LC (PGRP-LC) expression in MTs, increased antimicrobial peptide (AMP) gene induction, and protected animals from bacterial infection. We show that desiccation increased ecdysone synthesis in MTs, while inhibition of ecdysone synthesis or ecdysone receptor expression, specifically within MTs, prevented induction of PGRP-LC and reduced protection from bacterial infection. Additionally, aged flies are constitutively water-stressed and have elevated levels of ecdysone and PGRP-LC. Conversely, adults aged at high relative humidity show less water loss and have reduced expression of PGRP-LC and AMPs.
conclusionsThe Drosophila renal system is an important contributor to host defense and can modulate immune responses in an organ autonomous manner, responding to environmental changes such as desiccation. Desiccation primes immune responsiveness by elevating PGRP-LC expression specifically in MTs. In response to desiccation, ecdysone is produced in MTs and acts in a paracrine fashion to increase PGRP-LC expression, immune responsiveness, and improve host defense. This activity of the renal system may contribute to the immunosenescence observed in Drosophila.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.