Evidence map›Paper›PMID 29855355›Full record

ArticleInfectious diseases of poverty2018

Mapping and modelling the impact of mass drug adminstration on filariasis prevalence in Myanmar.

Ni Ni Aye, Zaw Lin, Khin Nan Lon, Nay Yi Yi Linn, Thet Wai Nwe, Khin Mon Mon, Kapa Ramaiah, Hannah Betts, Louise A Kelly-Hope

Abstract read
In one paragraph

Article in Infectious diseases of poverty, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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  5. Lymphatic filariases and soil-transmitted helminthiases in Sri Lanka: the challenge of eliminating residual pockets of transmission.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ni Ni AyeMinistry of Health and Sports, Department of Public Health, Nay Pyi Taw, Myanmar.
Zaw LinMinistry of Health and Sports, Department of Public Health, Nay Pyi Taw, Myanmar. zawlinmcp@gmail.com.
Khin Nan LonMinistry of Health and Sports, Department of Public Health, Nay Pyi Taw, Myanmar.
Nay Yi Yi LinnMinistry of Health and Sports, Department of Public Health, Nay Pyi Taw, Myanmar.
Thet Wai NweMinistry of Health and Sports, Department of Public Health, Nay Pyi Taw, Myanmar.
Khin Mon MonMinistry of Health and Sports, Department of Public Health, Nay Pyi Taw, Myanmar.
Kapa RamaiahTagore Nagar, Pondicherry, India.
Hannah BettsDepartment of Parasitology, Centre for Neglected Tropical Diseases, Liverpool School of Tropical Medicine, Liverpool, UK.
Louise A Kelly-HopeDepartment of Parasitology, Centre for Neglected Tropical Diseases, Liverpool School of Tropical Medicine, Liverpool, UK. Louise.Kelly-Hope@lstmed.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLymphatic filariasis (LF) is endemic in Myanmar and targeted for elimination. To highlight the National Programme to Eliminate Lymphatic Filariasis (NPELF) progress between 2000 and 2014, this paper describes the geographical distribution of LF, the scale-up and impact of mass drug administration (MDA) implementation, and the first evidence of the decline in transmission in five districts.

methodsThe LF distribution was determined by mapping historical and baseline prevalence data collected by NPELF. Data on the MDA implementation, reported coverage rates and sentinel site surveillance were summarized. A statistical model was developed from the available prevalence data to predict prevalence at township level by year of measurement. Transmission assessment survey (TAS) methods, measuring antigenemia (Ag) prevalence in children, were used to determine whether prevalence was below a level where recrudescence is unlikely to occur.

resultsThe highest baseline LF prevalence was found in the Central Valley region. The MDA implementation activities scaled up to cover 45 districts, representing the majority of the endemic population, with drug coverage rates ranging from 60.0% to 98.5%. Challenges related to drug supply and local conflict were reported, and interrupted MDA in some districts. Overall, significant reductions in LF prevalence were found, especially after the first 2 to 3 rounds of MDA, which was supported by the corresponding model. The TAS activities in five districts found only two Ag positive children, resulting in all districts passing the critical threshold.

conclusionOverall, the Myanmar NPELF has made positive steps forward in the elimination of LF despite several challenges, however, it needs to maintain momentum, drawing on international stakeholder support, to aim towards the national and global goals of elimination.

Indexed as

Elephantiasis, FilarialFilaricidesGeographic MappingHumansMass Drug AdministrationModels, StatisticalMyanmarPrevalenceFilaricidesElephantiasisLymphatic filariasisMass drug administrationMyanmarNeglected tropical diseasesSurveillanceTransmission assessment surveysWuchereria bancrofti

Identifiers

PMID29855355
PMCPMC5984392

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.