Evidence map›Paper›PMID 29855353›Full record

ReviewNeural development2018

Homeostatic plasticity in neural development.

Nai-Wen Tien, Daniel Kerschensteiner

Abstract readReview
In one paragraph

Review in Neural development, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed.

  1. Review
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  10. EEG-based sensorimotor neurofeedback for motor neurorehabilitation in children and adults: A scoping review.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024
    Article
  11. Article
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  15. Diverging from the Norm: Reevaluating What Miniature Excitatory Postsynaptic Currents Tell Us about Homeostatic Synaptic Plasticity.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2024
    Review
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Nai-Wen TienDepartment of Ophthalmology and Visual Sciences, Washington University School of Medicine, Saint Louis, USA. tien@wustl.edu.
Daniel KerschensteinerDepartment of Ophthalmology and Visual Sciences, Washington University School of Medicine, Saint Louis, USA. kerschensteinerd@wustl.edu.ORCID 0000-0002-6794-9056

Funding

SYNAPTIC ORGANIZATION AND VISUAL PROCESSING IN INTERNEURON CIRCUITS OF THE RETINAR01EY026978 · NEI · WASHINGTON UNIVERSITY · PI Daniel Kerschensteiner · 2016 to 2026
$3.8M
Synapse rescue and neuroprotection in the retinaR01EY027411 · NEI · WASHINGTON UNIVERSITY · PI Daniel Kerschensteiner · 2017 to 2026
$3.4M
National Eye Institute (US) EY023441NEI NIH HHS EY026978NEI NIH HHS EY027411NEI NIH HHS R01 EY026978NEI NIH HHS R01 EY027411
6 · The paper itself

Abstract

Throughout life, neural circuits change their connectivity, especially during development, when neurons frequently extend and retract dendrites and axons, and form and eliminate synapses. In spite of their changing connectivity, neural circuits maintain relatively constant activity levels. Neural circuits achieve functional stability by homeostatic plasticity, which equipoises intrinsic excitability and synaptic strength, balances network excitation and inhibition, and coordinates changes in circuit connectivity. Here, we review how diverse mechanisms of homeostatic plasticity stabilize activity in developing neural circuits.

Indexed as

AnimalsHomeostasisHumansNerve NetNeuronal PlasticityNeuronsSynapsesExcitation/inhibition ratioHomeostatic plasticityIntrinsic excitabilityNeural developmentPatterned spontaneous activitySynaptic strength

Identifiers

PMID29855353
PMCPMC5984303

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.