ArticleMicrobiome2018
Oral microbiota in youth with perinatally acquired HIV infection.
Article in Microbiome, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01418014 (Adolescent Master Protocol), which is not on this map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Adolescent Master Protocol
Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- Signatures of oral microbiome in HIV-infected individuals with oral Kaposi's sarcoma and cell-associated KSHV DNA.PLoS pathogens · 2020Trial
- Unique Oral Microbiota Signatures and Neurocognitive Function in Adolescents with and without Perinatally Acquired HIV.Research square · 2026Article
- Mapping the oral microbiome in children with oral diseases using next-generation sequencing: a systematic review.Journal of oral microbiology · 2026Review
- Alterations of the Upper Respiratory Microbiome Among Children Living With HIV Infection in Botswana.The Journal of infectious diseases · 2025Article
- Human immunodeficiency virus and oral microbiota: mutual influence on the establishment of a viral gingival reservoir in individuals under antiretroviral therapy.Frontiers in cellular and infection microbiology · 2024Review
- Impact of HIV on the Oral Microbiome of Children Living in Sub-Saharan Africa, Determined by Using anMicrobiology spectrum · 2023Article
- HIV-Positive Patients on Antiretroviral Therapy Have an Altered Mucosal Intestinal but Not Oral Microbiome.Microbiology spectrum · 2023Article
- A decade of progress: bibliometric analysis of trends and hotspots in oral microbiome research (2013-2022).Frontiers in cellular and infection microbiology · 2023Article
- Dental caries and its association with the oral microbiomes and HIV in young children-Nigeria (DOMHaIN): a cohort study.BMC oral health · 2021Article
- Alterations in the oral microbiome in HIV infection: causes, effects and potential interventions.Chinese medical journal · 2021Review
- Changes in Conjunctival Microbiota Associated With HIV Infection and Antiretroviral Therapy.Investigative ophthalmology & visual science · 2021Observational
- HIV-Associated Interactions Between Oral Microbiota and Mucosal Immune Cells: Knowledge Gaps and Future Directions.Frontiers in immunology · 2021Review
- Oral Health Status of Young People Infected with HIV in High Epidemic Area of China.Journal of multidisciplinary healthcare · 2021Article
- Altered Salivary Microbiome in the Early Stage of HIV Infections among Young Chinese Men Who Have Sex with Men (MSM).Pathogens (Basel, Switzerland) · 2020Article
- Salivary metabolite levels in perinatally HIV-infected youth with periodontal disease.Metabolomics : Official journal of the Metabolomic Society · 2020Observational
- Immune status, and not HIV infection or exposure, drives the development of the oral microbiota.Scientific reports · 2020Article
- Bayesian variable selection for multivariate zero-inflated models: Application to microbiome count data.Biostatistics (Oxford, England) · 2020Article
- Current trends and new developments in HIV research and periodontal diseases.Periodontology 2000 · 2020Review
- Significant effect of HIV/HAART on oral microbiota using multivariate analysis.Scientific reports · 2019Article
- Microbiome Dependent Regulation of TFrontiers in immunology · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundMicrobially mediated oral diseases can signal underlying HIV/AIDS progression in HIV-infected adults. The role of the oral microbiota in HIV-infected youth is not known. The Adolescent Master Protocol of the Pediatric HIV/AIDS Cohort Study is a longitudinal study of perinatally HIV-infected (PHIV) and HIV-exposed, uninfected (PHEU) youth. We compared oral microbiome levels and associations with caries or periodontitis in 154 PHIV and 100 PHEU youth.
resultsSpecies richness and alpha diversity differed little between PHIV and PHEU youth. Group differences in average counts met the significance threshold for six taxa; two Corynebacterium species were lower in PHIV and met thresholds for noteworthiness. Several known periodontitis-associated organisms (Prevotella nigrescens, Tannerella forsythia, Aggregatibacter actinomycetemcomitans, and Filifactor alocis) exhibited expected associations with periodontitis in PHEU youth, associations not observed in PHIV youth. In both groups, odds of caries increased with counts of taxa in four genera, Streptococcus, Scardovia, Bifidobacterium, and Lactobacillus.
conclusionsThe microbiomes of PHIV and PHEU youth were similar, although PHIV youth seemed to have fewer "health"-associated taxa such as Corynebacterium species. These results are consistent with the hypothesis that HIV infection, or its treatment, may contribute to oral dysbiosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.