Evidence map›Paper›PMID 29855286›Full record

ArticleBMC pediatrics2018

Maternal thyroid disorder in pregnancy and risk of cerebral palsy in the child: a population-based cohort study.

Tanja Gram Petersen, Anne-Marie Nybo Andersen, Peter Uldall, Nigel Paneth, Ulla Feldt-Rasmussen, Mette Christophersen Tollånes, Katrine Strandberg-Larsen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Tanja Gram PetersenSection of Social Medicine, Department of Public Health, University of Copenhagen, Gothersgade 160, 1123, Copenhagen, Denmark. tagp@sund.ku.dk.ORCID 0000-0002-6059-001X
Anne-Marie Nybo AndersenSection of Social Medicine, Department of Public Health, University of Copenhagen, Gothersgade 160, 1123, Copenhagen, Denmark.
Peter UldallPediatric Department at Rigshospitalet, Juliane Maries Vej 8, 2100, Copenhagen, Denmark.
Nigel PanethDepartment of Epidemiology & Biostatistics and Department of Pediatrics and Human Development, Michigan State University, 909 Fee Road, East Lansing, MI, 48824, USA.
Ulla Feldt-RasmussenDepartment of Medical Endocrinology at Rigshospitalet, Ole Maaloees Vej 26, 2200, Copenhagen, Denmark.
Mette Christophersen TollånesDomain for Mental and Physical Health at Norwegian Institute of Public Health, Kalfarveien 31, 5020, Bergen, Norway.
Katrine Strandberg-LarsenSection of Social Medicine, Department of Public Health, University of Copenhagen, Gothersgade 160, 1123, Copenhagen, Denmark.
University of Copenhagen · DKRigshospitalet · DKMichigan State University · USNorwegian Institute of Public Health · NO

Funding

Gene-Environment Interactions in an Autism Birth CohortU01NS047537 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LIPKIN, W. IAN · 2003 to 2013
$27.0M
NIEHS NIH HHS N01 ES075558NINDS NIH HHS U01 NS047537
6 · The paper itself

Abstract

backgroundCerebral palsy is the most frequent motor disability in childhood, but little is known about its etiology. It has been suggested that cerebral palsy risk may be increased by prenatal thyroid hormone disturbances. The objective of this study was to investigate whether maternal thyroid disorder is associated with increased risk of cerebral palsy.

methodsA population-based cohort study using two study populations. 1) 1,270,079 children born in Denmark 1979-2007 identified in nationwide registers, and 2) 192,918 children born 1996-2009 recruited into the Danish National Birth Cohort and The Norwegian Mother and Child Cohort study, combined in the MOthers and BAbies in Norway and Denmark (MOBAND) collaboration cohort. Register-based and self-reported information on maternal thyroid disorder was studied in relation to risk of cerebral palsy and its unilateral and bilateral spastic subtypes using multiple logistic regression. Children were followed from the age of 1 year to the age of 6 years, and cerebral palsy was identified in nationwide registers with verified diagnoses.

resultsIn register data, hypothyroidism was recognized in 12,929 (1.0%), hyperthyroidism in 9943 (0.8%), and unclassifiable thyroid disorder in 753 (< 0.1%) of the mothers. The odds ratio for an association between maternal thyroid disorder and bilateral spastic cerebral palsy was 1.0 (95% CI: 0.7-1.5). Maternal thyroid disorder identified during pregnancy was associated with elevated risk of unilateral spastic cerebral palsy (odds ratio 3.1 (95% CI: 1.2-8.4)). In MOBAND, 3042 (1.6%) of the mothers reported a thyroid disorder in pregnancy, which was not associated with cerebral palsy overall (odds ratio 1.2 (95% CI: 0.6-2.4)).

conclusionsMaternal thyroid disorder overall was not related to bilateral spastic cerebral palsy, but maternal thyroid disorder identified in pregnancy was associated with increased risk of unilateral spastic cerebral palsy. These findings should be replicated in studies making use of maternal blood samples.

Indexed as

Pregnancy ComplicationsPrenatal Exposure Delayed EffectsAdultCerebral PalsyChildChild, PreschoolCohort StudiesDenmarkFemaleHumansInfantInfant, NewbornMaleNorwayPregnancyRegistriesCerebral palsyMaternal thyroid disorderPregnancyPrenatal exposureRegister-based cohortThe Danish National Birth CohortThe Norwegian mother and child cohort study

Identifiers

PMID29855286
PMCPMC5977482
OpenAlexW2807289888

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.