ArticleBrain connectivity2019
Transient Patterns of Functional Dysconnectivity in Clinical High Risk and Early Illness Schizophrenia Individuals Compared with Healthy Controls.
Article in Brain connectivity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Dynamic functional connectivity in borderline personality disorder: associations with trauma, emotion regulation and symptom severity.European archives of psychiatry and clinical neuroscience · 2026Article
- Altered Brain-Behavior Association During Resting State is a Potential Psychosis Risk Marker.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Aberrant brain dynamics in individuals with clinical high risk of psychosis.Schizophrenia bulletin open · 2024Article
- Cortical Network Disruption Is Minimal in Early Stages of Psychosis.Schizophrenia bulletin open · 2024Article
- Aberrant dynamic functional network connectivity in type 2 diabetes mellitus individuals.Cognitive neurodynamics · 2023Article
- Dysconnectivity in Schizophrenia Revisited: Abnormal Temporal Organization of Dynamic Functional Connectivity in Patients With a First Episode of Psychosis.Schizophrenia bulletin · 2023Article
- Article
- Atypical Dynamic Functional Network Connectivity State Engagement during Social-Emotional Processing in Schizophrenia and Autism.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Multiframe Evolving Dynamic Functional ConnectivityFrontiers in neuroscience · 2022Article
- Relationship between Dynamic Blood-Oxygen-Level-Dependent Activity and Functional Network Connectivity: Characterization of Schizophrenia Subgroups.Brain connectivity · 2021Article
- Brain network dynamics during working memory are modulated by dopamine and diminished in schizophrenia.Nature communications · 2021Article
- Whole-Brain Functional Network Connectivity Abnormalities in Affective and Non-Affective Early Phase Psychosis.Frontiers in neuroscience · 2021Article
- State-Dependent Functional Dysconnectivity in Youth With Psychosis Spectrum Symptoms.Schizophrenia bulletin · 2020Article
- An imbalance between functional segregation and integration in patients with pontine stroke: A dynamic functional network connectivity study.NeuroImage. Clinical · 2020Article
- Hub Patterns-Based Detection of Dynamic Functional Network Metastates in Resting State: A Test-Retest Analysis.Frontiers in neuroscience · 2019Article
- Symptom networks and working memory in schizophrenia: a multi-methodological cross-sectional study from phenotype to endophenotype.International journal of clinical and health psychology : IJCHPArticle
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Schizophrenia shows abnormal dynamic functional network connectivity (dFNC), but it is unclear whether these abnormalities are present early in the illness course or precede illness onset in individuals at clinical high risk (CHR) for psychosis. We examined dFNC from resting-state functional magnetic resonance imaging data in CHR (n = 53), early illness schizophrenia (ESZ; n = 58), and healthy control (HC; n = 70) individuals. We applied a sliding temporal window approach capturing five distinct dFNC states. In ESZ patients, the likelihood of transitioning from state 4, a state that exhibited greater cortical-subcortical hyperconnectivity and also lacked typically observed anticorrelation between the default mode network and other functional networks, to a hypoconnected state was increased compared with HC and CHR groups. Furthermore, we investigated the interaction of group and state on dFNC. Overall, HC individuals showed significant changes of connectivity between states that were absent or altered in ESZ patients and CHR individuals. Connectivity differences between groups were identified primarily in two out of the five states, in particular, between HC and ESZ groups. In summary, it appears that the interaction effect was mostly driven by (1) dynamic connectivity changes in HC that were abnormal in CHR and ESZ individuals and (2) the fact that dysconnectivity between groups was only present in some states. These findings underscore the likelihood that abnormalities are present not only in static FNC but also in dFNC, in individuals at CHR for schizophrenia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.