ArticleBrain and behavior2018
Temporary conductive hearing loss in early life impairs spatial memory of rats in adulthood.
Article in Brain and behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- Developmental timing of auditory deprivation influences spatial memory and hippocampal plasticity in rats.Scientific reports · 2025Article
- Effects of Auditory Training on Parvalbumin-Expressing Interneurons in Brain Regions Associated with Task Demands.Molecular neurobiology · 2025Article
- Role of early hearing aid experience in speech recognition in patients with bilateral congenital microtia following Bonebridge implantation: a retrospective cohort study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2024Article
- Developmental Exposure to Bisphenol a Degrades Auditory Cortical Processing in Rats.Neuroscience bulletin · 2022Article
- The hearing hippocampus.Progress in neurobiology · 2022Review
- Noise as a cause of neurodegenerative disorders: molecular and cellular mechanisms.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Review
- Unexpected Consequences of Noise-Induced Hearing Loss: Impaired Hippocampal Neurogenesis, Memory, and Stress.Frontiers in integrative neuroscience · 2022Review
- Loss of Brain-Derived Neurotrophic Factor Mediates Inhibition of Hippocampal Long-Term Potentiation by High-Intensity Sound.Cellular and molecular neurobiology · 2021Article
- Unilateral Conductive Hearing Loss Disrupts the Developmental Refinement of Binaural Processing in the Rat Primary Auditory Cortex.Frontiers in neuroscience · 2021Article
- Increased hippocampal GABAergic inhibition after long-term high-intensity sound exposure.PloS one · 2019Article
- Temporary conductive hearing loss in early life impairs spatial memory of rats in adulthood.Brain and behavior · 2018Article
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionIt is known that an interruption of acoustic input in early life will result in abnormal development of the auditory system. Here, we further show that this negative impact actually spans beyond the auditory system to the hippocampus, a system critical for spatial memory.
methodsWe induced a temporary conductive hearing loss (TCHL) in P14 rats by perforating the eardrum and allowing it to heal. The Morris water maze and Y-maze tests were deployed to evaluate spatial memory of the rats. Electrophysiological recordings and anatomical analysis were made to evaluate functional and structural changes in the hippocampus following TCHL.
resultsThe rats with the TCHL had nearly normal hearing at P42, but had a decreased performance with the Morris water maze and Y-maze tests compared with the control group. A functional deficit in the hippocampus of the rats with the TCHL was found as revealed by the depressed long-term potentiation and the reduced NMDA receptor-mediated postsynaptic current. A structural deficit in the hippocampus of those animals was also found as revealed the abnormal expression of the NMDA receptors, the decreased number of dendritic spines, the reduced postsynaptic density and the reduced level of neurogenesis.
conclusionsOur study demonstrates that even temporary auditory sensory deprivation in early life of rats results in abnormal development of the hippocampus and consequently impairs spatial memory in adulthood.
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