Evidence map›Paper›PMID 29855030›Full record

ArticlePhotochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology2018

Insulin hexamer dissociation dynamics revealed by photoinduced T-jumps and time-resolved X-ray solution scattering.

Dolev Rimmerman, Denis Leshchev, Darren J Hsu, Jiyun Hong, Baxter Abraham, Irina Kosheleva, Robert Henning, Lin X Chen

Abstract read
In one paragraph

Article in Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
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  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Time-resolved X-ray scattering studies of proteins.Current opinion in structural biology · 2021
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dolev RimmermanDepartment of Chemistry, Northwestern University, Evanston, Illinois 60208, USA. l-chen@northwestern.edu.
Denis Leshchev
Darren J Hsu
Jiyun Hong
Baxter Abraham
Irina Kosheleva
Robert Henning
Lin X Chen

Funding

Capturing Transient Protein Structures on Multiple Spatial and Temporal ScalesR01GM115761 · NIGMS · NORTHWESTERN UNIVERSITY · PI CHEN, LIN X · 2015 to 2023
$3.0M
BioCARS: A Synchrotron Structure Biology ResourceR24GM111072 · NIGMS · UNIVERSITY OF CHICAGO · PI MOFFAT, JOHN KEITH · 2013 to 2016
$2.3M
NIGMS NIH HHS R01 GM115761NIGMS NIH HHS R24 GM111072
6 · The paper itself

Abstract

The structural dynamics of insulin hexamer dissociation were studied by the photoinduced temperature jump technique and monitored by time-resolved X-ray scattering. The process of hexamer dissociation was found to involve several transient intermediates, including an expanded hexamer and an unstable tetramer. Our findings provide insights into the mechanisms of protien-protein association.

Indexed as

Protein MultimerizationAnimalsCattleInsulinKineticsModels, MolecularScattering, Small AngleX-Ray DiffractionInsulin

Identifiers

PMID29855030
PMCPMC6041135

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.