ArticleScience advances2018
A cerebellar adaptation to uncertain inputs.
Article in Science advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed.
- Local synaptic inhibition mediates cerebellar granule cell pattern separation and enables learned sensorimotor associations.Nature neuroscience · 2024Article
- Emergence of syntax and word prediction in an artificial neural circuit of the cerebellum.Nature communications · 2024Article
- Discrimination training affects stimulus generalization in mice during Pavlovian eyeblink conditioning.Frontiers in behavioral neuroscience · 2024Article
- Accessible and reliable neurometric testing in humans using a smartphone platform.Scientific reports · 2023Article
- Article
- Resistance, vulnerability and resilience: A review of the cognitive cerebellum in aging and neurodegenerative diseases.Neurobiology of learning and memory · 2020Review
- Article
- Intrinsic excitement in cerebellar nuclei neurons during learning.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- Article
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Authors and funding
4 authors.
Funding
Abstract
Noise and variability are inherent and unavoidable features of neural processing. Despite this physiological challenge, brain systems function well, suggesting the existence of adaptations that cope with noise. We report a novel adaptation that the cerebellum implements to maintain correct responses in the face of ambiguous inputs. We found that under these conditions, the cerebellum used a probabilistic binary choice: Although the probability of behavioral response gradually increased or decreased depending on the degree of similarity between current and trained inputs, the size of response remained constant. That way the cerebellum kept responses adaptive to trained input corrupted by noise while minimizing false responses to novel stimuli. Recordings and analysis of Purkinje cells activity showed that the binary choice is made in the cerebellar cortex. Results from large-scale simulation suggest that internal feedback from cerebellar nucleus back to cerebellar cortex plays a critical role in implementation of binary choice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.