Evidence map›Paper›PMID 29854897›Full record

ArticleData in brief2018

Characterization of the transient middle cerebral artery occlusion model of ischemic stroke in a HuR transgenic mouse line.

A Ardelt, R Carpenter, I Iwuchukwu, A Zhang, W Lin, E Kosciuczuk, C Hinkson, T Rebeiz, S Reitz, P King

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Data in brief, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

A ArdeltDepartment of Neurology, University of Chicago, 5841 S. Maryland Ave, MC2030, Chicago, IL 60637, USA.
R CarpenterDepartment of Neurology, University of Chicago, 5841 S. Maryland Ave, MC2030, Chicago, IL 60637, USA.
I IwuchukwuDepartment of Neurocritical Care, Ochsner Medical Center, 1514 Jefferson Hwy., New Orleans, LA 70121, USA.
A ZhangDepartment of Neurology, University of Chicago, 5841 S. Maryland Ave, MC2030, Chicago, IL 60637, USA.
W LinDepartment of Neurology, University of Chicago, 5841 S. Maryland Ave, MC2030, Chicago, IL 60637, USA.
E KosciuczukDivision of Hematology-Oncology, Northwestern University, 675 North St. Clair, Chicago, IL 60611, USA.
C HinksonDepartment of Neurology, University of Chicago, 5841 S. Maryland Ave, MC2030, Chicago, IL 60637, USA.
T RebeizDepartment of Neurology, University of Chicago, 5841 S. Maryland Ave, MC2030, Chicago, IL 60637, USA.
S ReitzDepartment of Neurology, University of Chicago, 5841 S. Maryland Ave, MC2030, Chicago, IL 60637, USA.
P KingDepartment of Neurology, University of Alabama at Birmingham, 1720 7th Sve South and the Birmingham VA Medical Center, Birmingham, AL 35233, USA.
University of Chicago · USNorthwestern University · USOchsner Medical Center · USUniversity of Alabama at Birmingham · US

Funding

TRANSLATIONAL RESEARCH UNIVERSITY OF CHICAGO: CLINICAL TRIALSUL1RR024999 · NCRR · UNIVERSITY OF CHICAGO · PI SOLWAY, JULIAN · 2007 to 2011
$25.3M
Alabama Neuroscience Blueprint Core CenterP30NS057098 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SWEATT, JOHN DAVID · 2006 to 2010
$9.5M
The Role of HuR in mutant SOD1 dysregulation of VEGF mRNA ProcessingR01NS064133 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KING, PETER H · 2008 to 2011
$1.2M
Molecular Signatures of Amyotrophic Lateral Sclerosis in Skeletal MuscleR21NS085497 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KING, PETER H · 2013 to 2014
$402k
The Role of the Terminal Complement Pathway in ALSR21NS081743 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BARNUM, SCOTT R · 2013 to 2014
$401k
NCRR NIH HHS UL1 RR024999NINDS NIH HHS P30 NS057098NINDS NIH HHS R01 NS064133NINDS NIH HHS R21 NS081743NINDS NIH HHS R21 NS085497
6 · The paper itself

Abstract

This set of experiments characterizes a model of transient cerebral ischemic stroke in a transgenic (Tg) mouse line in which the glial fibrillary acidic protein (GFAP) promoter is utilized to drive expression of a human RNA-binding protein, HuR. Additionally, the effect of cerebral ischemia on the expression of endogenous Hu proteins is presented.

Identifiers

PMID29854897
PMCPMC5972843
OpenAlexW2765608056

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.