Evidence map›Paper›PMID 29854826›Full record

ArticleJournal of veterinary medicine2018

Suspected Lonely Mouse Syndrome as a Cage Effect in a Drug Safety Study.

Xiaobu Ye, MariaLisa Itzoe, Rachel Sarabia-Estrada, Louis DeTolla, Betty M Tyler, Michael Guarnieri

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of veterinary medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Xiaobu YeDepartment of Neurological Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA.
MariaLisa ItzoeDepartment of Neurological Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Rachel Sarabia-EstradaDepartment of Neurological Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Louis DeTollaSchool of Medicine, Departments of Pathology, Medicine, Epidemiology and Public Health and the Program of Comparative Medicine, University of Maryland, Baltimore, MD, USA.
Betty M TylerDepartment of Neurological Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-9800-6969
Michael GuarnieriDepartment of Neurological Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-3079-6746
Johns Hopkins University · USUniversity of Maryland, Baltimore · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Studies have demonstrated that buprenorphine, a front line drug for veterinary analgesia, may alleviate symptoms of chronic pain. A cage side observation protocol was used to record behavioral signs in a mouse clinical trial of extended release buprenorphine. A retrospective review of the observations for signs of pain and stress revealed that mice given a fivefold overdose of buprenorphine (16.25 mg/kg) showed lethargy and facial signs associated with stress. However, similar signs were observed in the drug-free control mice as early as Day 3 of single-cage housing. This appears to be the first report of cage effects in a clinical trial for a veterinary drug.

Identifiers

PMID29854826
PMCPMC5966667
OpenAlexW2800324073

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.