Observational studyBioMed research international2018
Can Clinical and Surgical Parameters Be Combined to Predict How Long It Will Take a Tibia Fracture to Heal? A Prospective Multicentre Observational Study: The FRACTING Study.
Abstract readMulticenter StudyObservational Study
In one paragraph
Observational study in BioMed research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Performance of prediction models for delayed union and nonunion after fracture: a systematic review and meta-analysis.BMC musculoskeletal disorders · 2026Pooled it
- Automated and manual model creation workflows are equally reliable for virtual mechanical testing of ovine bone and fracture healing.Scientific reports · 2025Article
- The role of electrical stimulation in bone regeneration: mechanistic insights and therapeutic advances.Bioelectronic medicine · 2025Review
- Time to consider fracture nonunion an orphan disease? An update into pathophysiology, epidemiology and therapeutic solutions.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Review
- Three predictive scores compared in a retrospective multicenter study of nonunion tibial shaft fracture.World journal of orthopedics · 2024Article
- Treatment of Femoral Shaft Pseudarthrosis, Case Series and Medico-Legal Implications.Journal of clinical medicine · 2022Article
- Pulsed electromagnetic fields after intramedullary nailing of tibial fractures: a case control study.International orthopaedics · 2021Article
- Pilot study of micromotion nailing for mechanical stimulation of tibial fracture healing.Bone & joint open · 2021Article
- Scoring systems for early prediction of tibial fracture non-union: an update.International orthopaedics · 2021Article
- Pulsed Electromagnetic Fields in Bone Healing: Molecular Pathways and Clinical Applications.International journal of molecular sciences · 2021Review
- Poller blocking screw augmentation to treat delayed union of proximal tibial shaft fracture after locked IM nailing.Acta bio-medica : Atenei Parmensis · 2021Article
- The biology and treatment of acute long-bones diaphyseal fractures: Overview of the current options for bone healing enhancement.Bone reports · 2020Review
- Synthetic Bone Substitutes and Mechanical Devices for the Augmentation of Osteoporotic Proximal Humeral Fractures: A Systematic Review of Clinical Studies.Journal of functional biomaterials · 2020Review
- Pulsed Electromagnetic Field Stimulation of Bone Healing and Joint Preservation: Cellular Mechanisms of Skeletal Response.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2020Review
- The Treatment of Acute Diaphyseal Long-bones Fractures with Orthobiologics and Pharmacological Interventions for Bone Healing Enhancement: A Systematic Review of Clinical Evidence.Bioengineering (Basel, Switzerland) · 2020Review
- Possible Assessment of Calf Venous Pump Efficiency by Computational Fluid Dynamics Approach.Frontiers in physiology · 2020Article
- Translational Insights into Extremely Low Frequency Pulsed Electromagnetic Fields (ELF-PEMFs) for Bone Regeneration after Trauma and Orthopedic Surgery.Journal of clinical medicine · 2019Review
- Pulsed Electromagnetic Field Therapy Improves Osseous Consolidation after High Tibial Osteotomy in Elderly Patients-A Randomized, Placebo-Controlled, Double-Blind Trial.Journal of clinical medicine · 2019Article
Corrections and comments
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Authors and funding
79 authors.
Leo MassariOrthopaedic and Traumatology Department, "S. Anna" Hospital, University of Ferrara, Ferrara, Italy.ORCID 0000-0001-6198-2122
Francesco BenazzoOrthopaedic and Traumatology Department, IRCCS Foundation "San Matteo" Hospital, University of Pavia, Pavia, Italy.
Francesco FalezOrthopaedic and Traumatology Department, "Santo Spirito in Sassia" Hospital, Rome, Italy.
Ruggero CadossiResearch and Development, IGEA Clinical Biophysics, Carpi, Modena, Italy.
Dario PerugiaOrthopaedic and Traumatology Department, "Sant'Andrea" Hospital, Rome, Italy.
Luca PietrograndeHealth Sciences Department, Operative Unit of Orthopaedics and Traumatology, "San Paolo" Hospital, University of Milan, Milan, Italy.ORCID 0000-0002-2417-2638
Domenico Costantino AlojOrthopaedic, Traumatology and Rehabilitation Department, II Orthopaedics Clinic, CTO Hospital, Torino, Italy.
Antonio CaponeOrthopaedic Department, University of Cagliari, Cagliari, Italy.
Michele D'ArienzoOrthopaedic and Traumatology Department, "Paolo Giaccone" Hospital, University of Palermo, Palermo, Italy.
Matteo CadossiDepartment of Orthopaedic Surgery, Rizzoli Orthopaedic Institute, University of Bologna, Bologna, Italy.
Vincenzo LorussoOrthopaedic and Traumatology Department, "S. Anna" Hospital, University of Ferrara, Ferrara, Italy.
Gaetano CarusoOrthopaedic and Traumatology Department, "S. Anna" Hospital, University of Ferrara, Ferrara, Italy.
Matteo GhiaraOrthopaedic and Traumatology Department, IRCCS Foundation "San Matteo" Hospital, University of Pavia, Pavia, Italy.
Luigi CiolliOrthopaedic and Traumatology Department, "Santo Spirito in Sassia" Hospital, Rome, Italy.
Filippo La CavaOrthopaedic and Traumatology Department, "Santo Spirito in Sassia" Hospital, Rome, Italy.
Marco GuidiOrthopaedic and Traumatology Department, "Sant'Andrea" Hospital, Rome, Italy.ORCID 0000-0002-4005-0331
Filippo CastoldiOrthopaedic, Traumatology and Rehabilitation Department, II Orthopaedics Clinic, CTO Hospital, Torino, Italy.
Giuseppe MarongiuOrthopaedic Department, University of Cagliari, Cagliari, Italy.
Alessandra La GattutaOrthopaedic and Traumatology Department, "Paolo Giaccone" Hospital, University of Palermo, Palermo, Italy.
Dario Dell'OmoTranslational Research on New Surgical and Medical Technologies Department, Orthopaedics and Traumatology II°, University of Pisa, Pisa, Italy.
Michelangelo ScaglioneTranslational Research on New Surgical and Medical Technologies Department, Orthopaedics and Traumatology II°, University of Pisa, Pisa, Italy.
Sandro GianniniDepartment of Orthopaedic Surgery, Rizzoli Orthopaedic Institute, University of Bologna, Bologna, Italy.
Mattia FortinaOrthopaedics and Traumatology Clinic, "S. M. alle Scotte" Hospital, University of Siena, Siena, Italy.ORCID 0000-0002-4971-7382
Alberto RivaOrthopaedics and Traumatology Clinic, "S. M. alle Scotte" Hospital, University of Siena, Siena, Italy.
Pier Luigi De PalmaClinical and Molecular Science Department, Faculty of Medicine, Polytechnic University of Marche, Ancona, Italy.
Antonio Pompilio GiganteClinical and Molecular Science Department, Faculty of Medicine, Polytechnic University of Marche, Ancona, Italy.
Biagio MorettiBasic Medical Science, Neurosciences and Sensory Organs Department, University of Bari, Bari, Italy.
Giuseppe SolarinoBasic Medical Science, Neurosciences and Sensory Organs Department, University of Bari, Bari, Italy.
Francesco LijoiOrthopaedic and Trauma Department, "Morgagni-Pierantoni" Hospital, Forlì, Italy.
Giovanni GiordanoOrthopaedic and Trauma Department, "Morgagni-Pierantoni" Hospital, Forlì, Italy.
Pier Giorgio LondiniOrthopaedic and Traumatology Department, "Misericordia" Hospital ASL 9, Grosseto, Italy.
Danilo CastellanoOrthopaedic and Traumatology Department, "Misericordia" Hospital ASL 9, Grosseto, Italy.
Giuseppe SessaSurgery Department, "Vittorio Emanuele" Hospital, University of Catania, Catania, Italy.
Luciano CostarellaSurgery Department, "Vittorio Emanuele" Hospital, University of Catania, Catania, Italy.
Antonio BarileOrthopaedic and Trauma Department, "San Michele" Nursing Home Hospital, Maddaloni, Caserta, Italy.
Mariano BorrelliOrthopaedic and Trauma Department, "San Michele" Nursing Home Hospital, Maddaloni, Caserta, Italy.
Attilio RotaOrthopaedic and Traumatology Department, "Sandro Pertini" Hospital, ASL RMB, Rome, Italy.
Raffaele FontanaOrthopaedic and Traumatology Department, "Sandro Pertini" Hospital, ASL RMB, Rome, Italy.
Alberto MomoliOrthopaedic and Traumatology Department, "San Bortolo" Hospital, Vicenza, Italy.
Andrea MicaglioOrthopaedic and Traumatology Department, "San Bortolo" Hospital, Vicenza, Italy.
Guido BassiOrthopaedic and Traumatology Department, A.O. Pavia Voghera Hospital, Pavia, Italy.
Rossano Stefano CornacchiaOrthopaedic and Traumatology Unit, Ariano Irpino Hospital, Avellino, Italy.
Claudio CastelliOrthopaedics and Trauma Department, "Papa Giovanni XXIII" Hospital, Bergamo, Italy.
Michele GiudiciOrthopaedics and Trauma Department, "Papa Giovanni XXIII" Hospital, Bergamo, Italy.
Mauro MonesiOrthopaedic and Traumatology Department, "M. Bufalini" Hospital, Cesena, Italy.
Luigi Branca VerganoOrthopaedic and Traumatology Department, "M. Bufalini" Hospital, Cesena, Italy.
Pietro ManiscalcoOrthopaedic and Traumatology Department, "Guglielmo da Saliceto" Hospital, Piacenza, Italy.ORCID 0000-0002-5637-6774
M'Putu BulabulaOrthopaedic and Traumatology Department, "Guglielmo da Saliceto" Hospital, Piacenza, Italy.
Vincenzo ZottolaTraumatology and Reconstructive Surgery Functional Department, "S. Anna" Hospital, Como, Italy.
Auro CaraffaOrthopaedics and Traumatology Clinic, "S. M. Misericordia" Hospital, University of Perugia, Perugia, Italy.
Pierluigi AntinolfiOrthopaedics and Traumatology Clinic, "S. M. Misericordia" Hospital, University of Perugia, Perugia, Italy.
Fabio CataniOrthopaedic Surgery Department, Policlinico di Modena, University of Modena and Reggio Emilia, Modena, Italy.
Claudio SeverinoOrthopaedic Surgery Department, Policlinico di Modena, University of Modena and Reggio Emilia, Modena, Italy.
Enrico CastamanOrthopaedic and Traumatology Department, Montecchio Maggiore Hospital, Vicenza, Italy.
Carmelo ScialabbaOrthopaedic and Traumatology Department, Montecchio Maggiore Hospital, Vicenza, Italy.
Venceslao TovagliaOrthopaedic and Traumatology Department, CTO Hospital ASL RM "C", Rome, Italy.
Pietro CorsiOrthopaedic and Traumatology Department, CTO Hospital ASL RM "C", Rome, Italy.
Paolo FriemelOrthopaedic and Traumatology Department, Regione Veneto Azienda ULSS 18, Rovigo, Italy.
Marco RanellucciOrthopaedic and Traumatology Department, Regione Veneto Azienda ULSS 18, Rovigo, Italy.
Vincenzo CaiaffaOrthopaedics and Traumatology Department, "Di Venere" Hospital, Bari, Italy.
Giovanni MaraglinoOrthopaedics and Traumatology Department, "SS. Annunziata" Hospital, Taranto, Italy.
Roberto RossiOrthopaedic and Traumatology SCDU Department, "Mauriziano Umberto I" Hospital, University of Torino, Torino, Italy.ORCID 0000-0003-0386-8051
Antonio PastroneOrthopaedic and Traumatology SCDU Department, "Mauriziano Umberto I" Hospital, University of Torino, Torino, Italy.
Patrizio CaldoraOrthopaedic and Traumatology Surgery Department, "San Donato" Hospital, Arezzo, Italy.
Claudio CusumanoOrthopaedic and Traumatology Surgery Department, "San Donato" Hospital, Arezzo, Italy.
Pier Bruno SquarzinaOrthopaedics Department, NOCSAE Hospital, Modena, Italy.
Ugo BaschieriOrthopaedics Department, NOCSAE Hospital, Modena, Italy.
Ettore DemattèOrthopaedics and Traumatology Department, "Santa Chiara" Hospital, Trento, Italy.
Stefano GherardiOrthopaedics and Traumatology Department, "Santa Chiara" Hospital, Trento, Italy.
Carlo De RobertoOrthopaedics Unit, "Santa Maria di Loreto Mare" Hospital, Loreto Mare, Napoli, Italy.
Alberto BelluatiSpecialized Surgery Department, "S. Maria delle Croci" Hospital, Ravenna, Italy.
Antonio GianniniSpecialized Surgery Department, "S. Maria delle Croci" Hospital, Ravenna, Italy.
Ciro VillaniOrthopaedic Department, Sapienza University of Rome, Rome, Italy.
Pietro PersianiOrthopaedic Department, Sapienza University of Rome, Rome, Italy.ORCID 0000-0001-5795-3337
Silvio DemitriOrthopaedic and Trauma Department, "Santa Maria della Misericordia" Hospital, AOUD Udine, Udine, Italy.
Bruno Di MaggioOrthopaedics and Traumatology Unit, Piedimonte Matese Hospital, Caserta, Italy.
Guglielmo AbateOrthopaedics and Traumatology Unit, Piedimonte Matese Hospital, Caserta, Italy.
Francesca De TerlizziResearch and Development, IGEA Clinical Biophysics, Carpi, Modena, Italy.
Stefania SettiResearch and Development, IGEA Clinical Biophysics, Carpi, Modena, Italy.ORCID 0000-0001-8990-5452
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHealing of tibia fractures occurs over a wide time range of months, with a number of risk factors contributing to prolonged healing. In this prospective, multicentre, observational study, we investigated the capability of FRACTING (tibia FRACTure prediction healING days) score, calculated soon after tibia fracture treatment, to predict healing time.
methodsThe study included 363 patients. Information on patient health, fracture morphology, and surgical treatment adopted were combined to calculate the FRACTING score. Fractures were considered healed when the patient was able to fully weight-bear without pain.
results319 fractures (88%) healed within 12 months from treatment. Forty-four fractures healed after 12 months or underwent a second surgery. FRACTING score positively correlated with days to healing:
conclusionsThis study shows that the FRACTING score can be employed both to predict months needed for fracture healing and to identify immediately after treatment patients at risk of prolonged healing. In patients with high score values, new pharmacological and nonpharmacological treatments to enhance osteogenesis could be tested selectively, which may finally result in reduced disability time and health cost savings.
Indexed as
AdolescentAdultFemaleFracture HealingHumansMaleMiddle AgedOsteogenesisProspective StudiesReproducibility of ResultsTibiaTibial FracturesTreatment OutcomeYoung Adult
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