ArticleCanadian journal of gastroenterology & hepatology2018
Predictive Value of Adiposity Level, Metabolic Syndrome, and Insulin Resistance for the Risk of Nonalcoholic Fatty Liver Disease Diagnosis in Obese Children.
Article in Canadian journal of gastroenterology & hepatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- ATGL links insulin dysregulation to insulin resistance in adolescents with obesity and hepatosteatosis.The Journal of clinical investigation · 2025Trial
- Sex Differences in Body Composition and MASLD in Children With Overweight and Obesity.Acta paediatrica (Oslo, Norway : 1992) · 2025Article
- Altered extracellular matrix dynamics is associated with insulin resistance in adolescent children with obesity.Obesity (Silver Spring, Md.) · 2024Article
- Rising NAFLD and metabolic severity during the Sars-CoV-2 pandemic among children with obesity in the United States.Obesity (Silver Spring, Md.) · 2023Article
- Measurement and Modeling of the Optical Properties of Adipose Tissue in the Terahertz Range: Aspects of Disease Diagnosis.Diagnostics (Basel, Switzerland) · 2022Article
- Development of a prediction protocol for the screening of metabolic associated fatty liver disease in children with overweight or obesity.Pediatric obesity · 2022Article
- Factors early in life associated with hepatic steatosis.World journal of hepatology · 2022Article
- Indices of insulin resistance and adiposity can detect obesity-related morbidity in pediatrics.Saudi medical journal · 2022Article
- Screening for non-alcoholic fatty liver disease among obese and overweight children: Prevalence and predictors.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2022Article
- Single Point Insulin Sensitivity Estimator in Pediatric Non-Alcoholic Fatty Liver Disease.Frontiers in endocrinology · 2022Article
- Nonalcoholic fatty liver disease in children with obesity- observations from one clinical centre in the Western Pomerania region.Frontiers in endocrinology · 2022Article
- From Nonalcoholic Fatty Liver Disease (NAFLD) to Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD)-New Terminology in Pediatric Patients as a Step in Good Scientific Direction?Journal of clinical medicine · 2021Review
- Non-Alcoholic Fatty Liver Disease in Obese Youth With Insulin Resistance and Type 2 Diabetes.Frontiers in endocrinology · 2021Review
- New Perspectives on Genetic Prediction for Pediatric Metabolic Associated Fatty Liver Disease.Frontiers in pediatrics · 2020Review
- Development of a Plasma Screening Panel for Pediatric Nonalcoholic Fatty Liver Disease Using Metabolomics.Hepatology communications · 2019Article
- NAFLD in children: new genes, new diagnostic modalities and new drugs.Nature reviews. Gastroenterology & hepatology · 2019Review
- Metabolic Syndrome Is Associated With Advanced Liver Fibrosis Among Pediatric Patients With Non-alcoholic Fatty Liver Disease.Frontiers in pediatrics · 2019Article
- The Liver in Children With Metabolic Syndrome.Frontiers in endocrinology · 2019Review
- Non-Alcoholic Fatty Liver Disease in Overweight Children: Role of Fructose Intake and Dietary Pattern.Nutrients · 2018Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in obese children. Early diagnosis and treatment are essential for curing or slowing down the disease progression. The aim of the study was to assess the prevalence of NAFLD in this population and to identify anthropometrical and metabolic risk factors for NAFLD prediction and its development. Material and Methods: The study included 108 obese children. Anthropometric measurements, NAFLD diagnosis (based on ALT level and/or liver ultrasound), and metabolic syndrome (MS) components were assessed in all patients. Patients were divided into groups with and without NAFLD. Results: NAFLD was diagnosed in 49 (45%) patients with similar prevalence in boys (27; 55.10%) and girls [22 (44.9%), Conclusions: NAFLD is a very common disease in obese children. NAFLD predictive risk factors include increased waist circumference, elevated WHR and WHtR, and elevated total cholesterol, triglycerides, and fasting insulin as well as elevated glucose and insulin concentration in the OGTT and HOMA-IR index. NAFLD increases the risk of potential cardiovascular complications expressed by diagnosis of metabolic syndrome. The best independent predictive risk factor for diagnosing NAFLD in obese children is fasting insulin > 18.9 uIU/ml.
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