Evidence map›Paper›PMID 29854714›Full record

ArticleCanadian journal of gastroenterology & hepatology2018

Alpha-Fetoprotein as a Predictive Marker for Patients with Hepatitis B-Related Acute-on-Chronic Liver Failure.

Xiaoping Wang, Caifei Shen, Jianjiang Yang, Xianjun Yang, Sen Qin, Haijun Zeng, Xiaoling Wu, Shanhong Tang, Weizheng Zeng

Open access · goldAbstract read
In one paragraph

Article in Canadian journal of gastroenterology & hepatology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 20 citations in OpenAlex.

  1. Trial
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  7. [A case of successful treatment of acute exacerbation of chronic hepatitis B combined with abnormally elevated alpha-fetoprotein].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2024
    Article
  8. Review
  9. Article
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  12. [Value of the monocyte-to-lymphocyte ratio in the prognostic evaluation of hepatitis B-related acute-on-chronic liver failure].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2022
    Article
  13. Review
  14. [Analysis of prognosis-related factors in patients with hepatitis B virus-related acute-on-chronic liver failure].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2021
    Article
  15. Biomolecules · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Xiaoping WangDepartment of Gastroenterology, Chengdu Military General Hospital, Chengdu, Sichuan, China.
Caifei ShenDepartment of Gastroenterology, Chengdu Military General Hospital, Chengdu, Sichuan, China.
Jianjiang YangDepartment of Gastroenterology, Chengdu Military General Hospital, Chengdu, Sichuan, China.
Xianjun YangChengdu Military Command Disease Prevention and Control Center, Chengdu, Sichuan, China.
Sen QinDepartment of Gastroenterology, Chengdu Military General Hospital, Chengdu, Sichuan, China.
Haijun ZengDepartment of Gastroenterology, Chengdu Military General Hospital, Chengdu, Sichuan, China.
Xiaoling WuDepartment of Gastroenterology, Chengdu Military General Hospital, Chengdu, Sichuan, China.
Shanhong TangDepartment of Gastroenterology, Chengdu Military General Hospital, Chengdu, Sichuan, China.ORCID 0000-0002-9617-6769
Weizheng ZengDepartment of Gastroenterology, Chengdu Military General Hospital, Chengdu, Sichuan, China.ORCID 0000-0002-9631-6039
Chengdu Military General Hospital · CNChengdu Center for Disease Control and Prevention · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aims: The value of alpha-fetoprotein (AFP) in hepatitis B-related acute-on-chronic liver failure (HBACLF) is not fully understood. The present study aimed to evaluate the prognostic effect of AFP on the prediction of HBACLF outcomes. Methods: We investigated a cohort of patients with HBACLF admitted from January 2013 to May 2017. The endpoint of followup was 180 days, death, or liver transplantation. AFP concentrations were estimated on admission. To make statistical comparisons, we used chi-squared test, receiver operating characteristic (ROC) curve analysis, survivorship curve analysis, and Cox proportional-hazards model. Results: A total of 92 patients (81.5% male, median age of 46 years) were included. Overall survival rate within 180 days was 43.48%, and the value of log Conclusion: AFP could be a useful marker to predict outcomes of acute-on-chronic liver failure.

Indexed as

Acute-On-Chronic Liver FailureAdolescentAdultAgedalpha-FetoproteinsBiomarkersChinaFemaleFollow-Up StudiesHepatitis B, ChronicHumansIncidenceMaleMiddle AgedPredictive Value of TestsPrognosisalpha-FetoproteinsBiomarkers

Identifiers

PMID29854714
PMCPMC5966688
OpenAlexW2801581376

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.