Evidence map›Paper›PMID 29854675›Full record

ReviewChonnam medical journal2018

Addressing the Side Effects of Contemporary Antidepressant Drugs: A Comprehensive Review.

Sheng-Min Wang, Changsu Han, Won-Myoung Bahk, Soo-Jung Lee, Ashwin A Patkar, Prakash S Masand, Chi-Un Pae

Open access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Chonnam medical journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 147 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
147citing papers in PubMed, 9 pooled it
14.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

147 citing papers in PubMed, 9 syntheses or guidelines pooled it, 290 citations in OpenAlex.

  1. Prophylactic Management of Vestibular Migraine: A Systematic Review.Annals of clinical and translational neurology · 2025
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87 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Sheng-Min WangDepartment of Psychiatry, The Catholic University of Korea College of Medicine, Seoul, Korea.
Changsu HanDepartment of Psychiatry, Korea University, College of Medicine, Seoul, Korea.
Won-Myoung BahkDepartment of Psychiatry, The Catholic University of Korea College of Medicine, Seoul, Korea.
Soo-Jung LeeDepartment of Psychiatry, The Catholic University of Korea College of Medicine, Seoul, Korea.
Ashwin A PatkarDepartment of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA.
Prakash S MasandGlobal Medical Education, New York, NY, USA.
Chi-Un PaeDepartment of Psychiatry, The Catholic University of Korea College of Medicine, Seoul, Korea.
Catholic University of Korea · KRDuke Medical Center · USKorea University · KRThe Catholic University of Korea Seoul St. Mary's Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Randomized trials have shown that selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) have better safety profiles than classical tricyclic antidepressants (TCAs). However, an increasing number of studies, including meta-analyses, naturalistic studies, and longer-term studies suggested that SSRIs and SNRIs are no less safe than TCAs. We focused on comparing the common side effects of TCAs with those of newer generation antidepressants including SSRIs, SNRIs, mirtazapine, and bupropion. The main purpose was to investigate safety profile differences among drug classes rather than the individual antidepressants, so studies containing comparison data on drug groups were prioritized. In terms of safety after overdose, the common belief on newer generation antidepressants having fewer side effects than TCAs appears to be true. TCAs were also associated with higher drop-out rates, lower tolerability, and higher cardiac side-effects. However, evidence regarding side effects including dry mouth, gastrointestinal side effects, hepatotoxicity, seizure, and weight has been inconsistent, some studies demonstrated the superiority of SSRIs and SNRIs over TCAs, while others found the opposite. Some other side effects such as sexual dysfunction, bleeding, and hyponatremia were more prominent with either SSRIs or SNRIs.

Indexed as

Antidepressive AgentsDepressive DisorderDrug-related Side Effects and Adverse Reactions

Identifiers

PMID29854675
PMCPMC5972123
OpenAlexW2804876758

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.