ArticleToxicology reports2018
Sex-dependent impact of Roundup on the rat gut microbiome.
Article in Toxicology reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 110 citations in OpenAlex.
- Towards ecological psychiatry: The herbicide glyphosate disrupts behavior through microbiota-gut-brain axis.Molecular psychiatry · 2026Article
- Glyphosate-Based Herbicides and Their Potential Impact on the Microbiota of Social Bees.Toxics · 2025Review
- Occurrence and profiles of glyphosate and aminomethylphosphonic acid in paired urine and feces of humans, cats, and dogs.Environment international · 2025Article
- Exposure to the herbicide glyphosate leads to inappropriate threat responses and alters gut microbial composition.Frontiers in toxicology · 2025Article
- Inhalation of 2,2',5,5'-tetrachlorobiphenyl (PCB52) causes changes to the gut microbiome throughout the gastrointestinal tract.Journal of hazardous materials · 2024Article
- Exposure to Environmental Pesticides and the Risk of Autism Spectrum Disorders: A Population-Based Case-Control Study.Medicina (Kaunas, Lithuania) · 2024Article
- Pesticides: Unintended Impact on the Hidden World of Gut Microbiota.Metabolites · 2024Review
- Long access heroin self-administration significantly alters gut microbiome composition and structure.Frontiers in psychiatry · 2024Article
- Evaluation of neurological behavior alterations and metabolic changes in mice under chronic glyphosate exposure.Archives of toxicology · 2024Article
- Gastrointestinal Microbial Ecology of Weaned Piglets Fed Diets with Different Levels of Glyphosate.Microbiology spectrum · 2023Article
- Pesticide exposure and the microbiota-gut-brain axis.The ISME journal · 2023Review
- Low-dose glyphosate exposure alters gut microbiota composition and modulates gut homeostasis.Environmental toxicology and pharmacology · 2023Article
- Association of Lifetime Exposure to Glyphosate and Aminomethylphosphonic Acid (AMPA) with Liver Inflammation and Metabolic Syndrome at Young Adulthood: Findings from the CHAMACOS Study.Environmental health perspectives · 2023Article
- Microbial gut dysbiosis induced by xenobiotics in model organisms and the relevance of experimental criteria: a minireview.Gut microbiome (Cambridge, England) · 2023Review
- Pesticides and the Microbiome-Gut-Brain Axis: Convergent Pathways in the Pathogenesis of Parkinson's Disease.Journal of Parkinson's disease · 2023Review
- Glyphosate and glyphosate-based herbicides (GBHs) induce phenotypic imipenem resistance in Pseudomonas aeruginosa.Scientific reports · 2022Article
- Impacts of Pesticides on Oral Cavity Health and Ecosystems: A Review.International journal of environmental research and public health · 2022Review
- Multi-Omics Strategies for Investigating the Microbiome in Toxicology Research.Toxicological sciences : an official journal of the Society of Toxicology · 2022Review
- Glyphosate induces immune dysregulation in honey bees.Animal microbiome · 2022Article
- A systematic review on the effects of nanomaterials on gut microbiota.Current research in microbial sciences · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A growing body of research suggests that dysbiosis of the gut microbiota induced by environmental pollutants, such as pesticides, could have a role in the development of metabolic disorders. We have examined the long-term effects of 3 doses of the Roundup(R) herbicide (made of glyphosate and formulants) on the gut microbiota in male and female Sprague-Dawley rats. A total of 141 bacteria families were identified by a 16S sequencing analysis approach. An OPLS-DA analysis revealed an increased Bacteroidetes family S24-7 and a decreased Lactobacillaceae in 8 out of the 9 females treated with 3 different doses of R (n = 3, for each dose). These effects were confirmed by repetitive sequence-based PCR fingerprinting showing a clustering of treated females. A culture-based method showed that R had a direct effect on rat gut microbiota. Cultivable species showed different sensitivities to R, including the presence of a high tolerant or resistant strain identified as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.