ArticleToxicology reports2018
Diclofenac - induced hepatotoxicity: Low dose of omega-3 fatty acids have more protective effects.
Article in Toxicology reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Silymarin alleviates diclofenac-induced hepatotoxicity in male Wistar rats: Histopathological investigation.Open veterinary journal · 2025Article
- Review
- Therapeutic effects of vitamin D and omega-3 supplementation on HFHS diet-induced endothelial dysfunction in Wistar rats.Current research in pharmacology and drug discovery · 2025Article
- Omega 3 fatty acids preserve testicular function by ameliorating BPF-induced dysthyroidism: role of p53/Bcl-2 signaling and proton pump activities.JBRA assisted reproduction · 2024Article
- Allicin and Omega-3 fatty acids attenuates acetaminophen mediated renal toxicity and modulates oxidative stress, and cell apoptosis in rats.Naunyn-Schmiedeberg's archives of pharmacology · 2024Article
- Polyherbal extract improves glycometabolic control in alloxan-induced diabetic ratsIranian journal of basic medical sciences · 2024Article
- Omega 3 fatty acid improves sexual and erectile function in BPF-treated rats by upregulating NO/cGMP signaling and steroidogenic enzymes activities.Scientific reports · 2023Article
- Carvacrol Exerts Anti-Inflammatory, Anti-Oxidative Stress and Hepatoprotective Effects Against Diclofenac-Induced Liver Injury in Male Rats.International journal of preventive medicine · 2023Article
- Development and Challenges of Diclofenac-Based Novel Therapeutics: Targeting Cancer and Complex Diseases.Cancers · 2022Review
- Amelioration of the hepatotoxic effects of nonsteroidal drugs using vitamin C and determination of their relationship with the lipid profile.Journal of Taibah University Medical Sciences · 2022Article
- Hepatoprotective Effect of Coenzyme Q10 in Rats with Diclofenac Toxicity.Archives of Razi Institute · 2022Article
- Hepatorenal protective activity of Artemisia against diclofenac toxicity in male rats.The Pan African medical journal · 2022Article
- Article
- Effect of omega-3 fatty acids supplementation on indirect blood markers of exercise-induced muscle damage: Systematic review and meta-analysis of randomized controlled trials.Food science & nutrition · 2021Review
- Pharmacological support to anti-arthritic prospective of physostigmine: a new approach.Inflammopharmacology · 2021Article
- Anti-arthritic activity ofIranian journal of basic medical sciences · 2021Article
- Cinnamon Aqueous Extract Attenuates Diclofenac Sodium and Oxytetracycline Mediated Hepato-Renal Toxicity and Modulates Oxidative Stress, Cell Apoptosis, and Inflammation in Male Albino Rats.Veterinary sciences · 2021Article
- Toxicity of diclofenac sodium salt in Yucatan minipigsToxicology reports · 2021Article
- Gallic acid mitigates diclofenac-induced liver toxicity by modulating oxidative stress and suppressingPharmaceutical biology · 2020Article
- Effect of Carotenoids fromMolecules (Basel, Switzerland) · 2020Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The global embrace of the Western dietary style has necessitated the need for supplementation with omega-3 fatty acids (N-3) to redress the imbalance in omega-6/omega-3 fatty acids ratio. Therefore, the study investigated the effects of pre-treatment with N-3 in adult male Wistar rats exposed to diclofenac sodium (DF). Twenty adult male Wistar rats were used for this study. They were divided into 4 groups of 5 rats each, which included: Group 1 - Normal control; Group 2 - DF control; Group 3 - Low N-3 + DF; and, Group 4 - High N-3 + DF. The rats in group 2 were administered DF (10 mg/kg b.w./day,
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