ReviewCritical care research and practice2018
Updates in Refractory Status Epilepticus.
Review in Critical care research and practice, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pharmacological management of seizures in patients with COVID-19: a systematic review.AAS open research · 2021Pooled it
- Review
- Review
- Mortality in older adults with epilepsy: An understudied entity.Epilepsia open · 2025Review
- Cardiac Abnormalities in Refractory Status Epilepticus-an Exploratory Study.Journal of epilepsy research · 2023Article
- A not so incidental 'incidentaloma' - pediatric ganglioneuroma-associated cerebellar degeneration and super-refractory status epilepticus: case report and literature review.Frontiers in neurology · 2023Article
- Clinico-biological markers for the prognosis of status epilepticus in adults.Journal of neurology · 2022Article
- Review
- Electroconvulsive seizure inhibits the mTOR signaling pathway via AMPK in the rat frontal cortex.Psychopharmacology · 2022Article
- Efficacy and safety of perampanel in refractory and super-refractory status epilepticus: cohort study of 81 patients and literature review.Journal of neurology · 2021Review
- First-line management of canine status epilepticus at home and in hospital-opportunities and limitations of the various administration routes of benzodiazepines.BMC veterinary research · 2021Review
- Convulsive status epilepticus in an emergency department in Cameroon.Epilepsy & behavior reports · 2021Article
- Super-refractory status epilepticus in a 29-year-old pregnant female.SAGE open medical case reports · 2021Article
- Inhibition of p38 MAPK regulates epileptic severity by decreasing expression levels of A1R and ENT1.Molecular medicine reports · 2020Article
- The Diagnostic Challenge of Seronegative Autoimmune Encephalitis With Super-Refractory Status Epilepticus.Cureus · 2020Article
- Electrographic predictors of successful weaning from anaesthetics in refractory status epilepticus.Brain : a journal of neurology · 2020Article
- Refractory Status Epilepticus Responsive to Electroacupuncture at Shuigou Acupoint: A Case Report.Frontiers in neurology · 2020Article
- FK506 Attenuated Pilocarpine-Induced Epilepsy by Reducing Inflammation in Rats.Frontiers in neurology · 2019Article
- To Wean or Not to Wean: Machine Learning to the Rescue.Epilepsy currentsArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Refractory status epilepticus is defined as persistent seizures despite appropriate use of two intravenous medications, one of which is a benzodiazepine. It can be seen in up to 40% of cases of status epilepticus with an acute symptomatic etiology as the most likely cause. New-onset refractory status epilepticus (NORSE) is a recently coined term for refractory status epilepticus where no apparent cause is found after initial testing. A large proportion of NORSE cases are eventually found to have an autoimmune etiology needing immunomodulatory treatment. Management of refractory status epilepticus involves treatment of an underlying etiology in addition to intravenous anesthetics and antiepileptic drugs. Alternative treatment options including diet therapies, electroconvulsive therapy, and surgical resection in case of a focal lesion should be considered. Short-term and long-term outcomes tend to be poor with significant morbidity and mortality with only one-third of patients reaching baseline neurological status.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.