Evidence map›Paper›PMID 29854318›Full record

ReviewOncotarget2018

Role of tumor microenvironment in ovarian cancer pathobiology.

Alia Ghoneum, Hesham Afify, Ziyan Salih, Michael Kelly, Neveen Said

Open access · diamondAbstract readReview
In one paragraph

Review in Oncotarget, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
10.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 65 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Alia GhoneumDepartment of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA.
Hesham AfifyDepartment of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA.
Ziyan SalihDepartment of Cancer Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA.
Michael KellyDepartment of Cancer Obstetrics and Gynecology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA.
Neveen SaidDepartment of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA.
Wake Forest University · US

Funding

Tumor Tissue CoreP30CA012197 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Ruben A. Mesa · 1985 to 2026
$55.4M
Regulation of Urinary Bladder Carcinogenesis and Progression by SPARCR01CA193437 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SAID, NEVEEN · 2016 to 2020
$1.8M
NCI NIH HHS P30 CA012197NCI NIH HHS R01 CA193437
6 · The paper itself

Abstract

Ovarian cancer is the fifth most common cancer affecting the female population and at present, stands as the most lethal gynecologic malignancy. Poor prognosis and low five-year survival rate are attributed to nonspecific symptoms and below par diagnostic criteria at early phases along with a lack of effective treatment at advanced stages. It is thus of utmost importance to understand ovarian carcinoma through several lenses including its molecular pathogenesis, epidemiology, histological subtypes, hereditary factors, diagnostic approaches and methods of treatment. Above all, it is crucial to dissect the role that the unique peritoneal tumor microenvironment plays in ovarian cancer progression and metastasis. This review seeks to highlight several important aspects of ovarian cancer pathobiology as a means to provide the necessary background to approach ovarian malignancies in the future.

Indexed as

ovarian cancerperitoneal metastasisresistance and recurrencetargeted therapytumor microenvironment

Identifiers

PMID29854318
PMCPMC5978268
OpenAlexW2799469776

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.