Evidence map›Paper›PMID 29854246›Full record

ArticleAMIA ... Annual Symposium proceedings. AMIA Symposium2017

Classifying Clinical Trial Eligibility Criteria to Facilitate Phased Cohort Identification Using Clinical Data Repositories.

Amy Y Wang, William J Lancaster, Matthew C Wyatt, Luke V Rasmussen, Daniel G Fort, James J Cimino

Abstract read
In one paragraph

Article in AMIA ... Annual Symposium proceedings. AMIA Symposium, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. LeafAI: query generator for clinical cohort discovery rivaling a human programmer.Journal of the American Medical Informatics Association : JAMIA · 2023
    Article
  3. Article
  4. Article
  5. Article
  6. Hybrid bag of approaches to characterize selection criteria for cohort identification.Journal of the American Medical Informatics Association : JAMIA · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Amy Y WangDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL.
William J LancasterDepartment of Biomedical Informatics, Vanderbilt University, Nashville, TN.
Matthew C WyattDepartment of Biomedical Informatics, Vanderbilt University, Nashville, TN.
Luke V RasmussenDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL.
Daniel G FortDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL.
James J CiminoInformatics Institute and Department of Medicine University of Alabama at Birmingham School of Medicine, Birmingham, AL.

Funding

UAB Center for Clinical and Translational Science (CCTS)UL1TR001417 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KIMBERLY, ROBERT P. · 2015 to 2018
$31.4M
National Infrastructure for Standardized and Portable EHR Phenotyping AlgorithmsR01GM105688 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI LUO, YUAN, PATHAK, JYOTISHMAN · 2013 to 2020
$5.7M
Northwestern University Clinical and Translational Science Institute (NUCATS)TL1TR001423 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI MCCOLLEY, SUSANNA A · 2015 to 2023
$5.0M
UAB Center for Clinical and Translational Sciences (CCTS)TL1TR001418 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SAAG, KENNETH G · 2015 to 2018
$2.1M
NCATS NIH HHS TL1 TR001418NCATS NIH HHS TL1 TR001423NCATS NIH HHS UL1 TR001417NIGMS NIH HHS R01 GM105688
6 · The paper itself

Abstract

A major challenge in using electronic health record repositories for research is the difficulty matching subject eligibility criteria to query capabilities of the repositories. We propose categories for study criteria corresponding to the effort needed for querying those criteria: "easy" (supporting automated queries), mixed (initial automated querying with manual review), "hard" (fully manual record review), and "impossible" or "point of enrollment" (not typically in health repositories). We obtained a sample of 292 criteria from 20 studies from ClinicalTrials.gov. Six independent reviewers, three each from two academic research institutions, rated criteria according to our four types. We observed high interrater reliability both within and between institutions. The analysis demonstrated typical features of criteria that map with varying levels of difficulty to repositories. We propose using these features to improve enrollment workflow through more standardized study criteria, self-service repository queries, and analyst-mediated retrievals.

Indexed as

Clinical Trials as TopicElectronic Health RecordsPatient SelectionDatabases as TopicDatabases, FactualHumansReproducibility of Results

Identifiers

PMID29854246
PMCPMC5977684

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.