Value of Genetics-informed Drug Dosing Guidance in Pregnant Women: A Needs Assessment with Obstetric Healthcare Providers at Johns Hopkins.

Casey L Overby, Phillip Thompkins, Harold Lehmann, Christopher G Chute, Jeanne S Sheffield

Abstract read

In one paragraph

Article in AMIA ... Annual Symposium proceedings. AMIA Symposium, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Casey L OverbyDivision of General Internal Medicine.

Phillip ThompkinsInstitute for Clinical & Translational Research.

Harold LehmannDivision of Health Sciences Informatics.

Christopher G ChuteDivision of General Internal Medicine.

Jeanne S SheffieldDivision of Maternal & Fetal Medicine; Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In order to better understand the potential value of genetics-informed drug dose guidance to obstetric healthcare providers at Johns Hopkins we administered a web-based needs assessment survey. The survey included questions about: 1) experience with adjusting drug doses during pregnancy; 2) comfort prescribing medications to pregnant women with chronic conditions; 3) awareness and use of genetics-informed dosing guidance; and 4) perceived value of access to services to provide genetics-informed dosing guidance. Among thirty-one respondents, 81% indicated an interest in access to genetics-informed drug dose guidance, particularly a mobile or electronic health record (EHR) application. It was indicated, however, that genetics is one of many characteristics that influence dose adjustments during pregnancy. This study motivates future research to help obstetric healthcare providers tailor drug dose to individual patients based upon models integrating multiple patient characteristics, including genetics.

Indexed as

Needs AssessmentObstetricsPhysiciansAntidepressive AgentsAntihypertensive AgentsAnti-Infective AgentsBaltimoreElectronic Health RecordsFemaleHumansMalePractice Guidelines as TopicPregnancyPregnancy ComplicationsPrescription DrugsAntidepressive AgentsAntihypertensive AgentsAnti-Infective AgentsPrescription Drugs

Identifiers

PMID29854203

PMCPMC5977707

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.