Evidence map›Paper›PMID 29854019›Full record

ArticleBehavioural neurology2018

Dynamic Evaluation of Notch Signaling-Mediated Angiogenesis in Ischemic Rats Using Magnetic Resonance Imaging.

Jia-Qi Tian, Jia-Jun Zheng, Xiao-Zhu Hao, Le-Kang Yin, Xiao-Xue Zhang, Chan-Chan Li, Xiao-Yuan Feng, Min Jiang, Hua-Ping Sun, Kang Zheng and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Behavioural neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 97% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Jia-Qi TianDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai 200040, China.ORCID 0000-0002-0903-7489
Jia-Jun ZhengDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, China.
Xiao-Zhu HaoDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai 200040, China.
Le-Kang YinDepartment of Radiology, Shanghai Chest hospital, Shanghai Jiao Tong University, Shanghai 200030, China.
Xiao-Xue ZhangDepartment of Radiotherapy, Shanghai Eastern Hepatobiliary Surgery Hospital, Shanghai 310114, China.
Chan-Chan LiDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai 200040, China.
Xiao-Yuan FengDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai 200040, China.
Min JiangInstitutes of Science and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200030, China.
Hua-Ping SunDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai 200040, China.ORCID 0000-0002-2766-1437
Kang ZhengDepartment of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, China.ORCID 0000-0002-8393-5674
Yan-Mei YangDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai 200040, China.ORCID 0000-0002-1972-4231
Fudan University · CNSecond Military Medical University · CNShanghai Jiao Tong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe Notch signaling pathway is involved in angiogenesis induced by brain ischemia and can be efficiently inhibited by the

methodsSprague-Dawley rats (

resultsSWI showed that DAPT treatment significantly enhanced angiogenesis in the ischemic boundary zone (IBZ) with respect to the control group, with local CBF in the angiogenic area elevated, along with increases in vascular density confirmed by histology.

conclusionTreatment of ischemic stroke with DAPT significantly augments angiogenesis, which promotes poststroke brain remodeling by elevating CBF level, and these processes can be dynamically monitored and evaluated by MRI.

Indexed as

AnimalsBrain IschemiaCerebrovascular CirculationDipeptidesDisease Models, AnimalMagnetic Resonance ImagingMaleNeovascularization, PhysiologicRatsRats, Sprague-DawleyReceptors, NotchSignal TransductionTime FactorsDipeptidesN-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl esterReceptors, Notch

Identifiers

PMID29854019
PMCPMC5960569
OpenAlexW2801133284

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.