Evidence map›Paper›PMID 29854010›Full record

ReviewJournal of circulating biomarkers

Evolution of proteomic biomarker for chronic liver disease: Promise into reality.

Krishna Sumanth Nallagangula, K N Shashidhar, V Lakshmaiah, Muninarayana

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of circulating biomarkers. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Krishna Sumanth NallagangulaDepartment of Biochemistry, Sri Devaraj Urs Medical College, SDUAHER, Karnataka, India.
K N ShashidharDepartment of Biochemistry, Sri Devaraj Urs Medical College, SDUAHER, Karnataka, India.
V LakshmaiahDepartment of Medicine, Sri Devaraj Urs Medical College, SDUAHER, Karnataka, India.
MuninarayanaDepartment of Community Medicine, Sri Devaraj Urs Medical College, SDUAHER, Karnataka, India.
Sri Devaraj Urs Academy of Higher Education and Research · INSri Devaraj Urs Medical College · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Liver is the vital organ for synthesis of proteins whose concentration in blood reflects liver dysfunction. Variations in protein domain can generate clinically significant biomarkers. Biomarker pipeline includes discovery of candidates, qualification, verification, assay optimization, and validation. Advances in proteomic approach can discover protein biomarker candidates based on "up-or-down" regulation or fold change in expression which is correlated with disease state. Despite numerous biomarker candidates been discovered, only few are useful in clinical practice which indicates the need for well-established validation regimen. Hence, the main purpose of this review is to understand the protein biomarker development and pitfalls. Companion diagnostics provide insights into potential cost-effective diagnosis for chronic liver disease.

Indexed as

assay optimizationbiomarker discoveryChronic liver diseasecompanion diagnosticspitfallsproteomicsspecificity and sensitivityvalidation strategies

Identifiers

PMID29854010
PMCPMC5971380
OpenAlexW2804107578

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.