Evidence map›Paper›PMID 29853946›Full record

ArticleEvidence-based complementary and alternative medicine : eCAM2018

Home-Based Transcutaneous Neuromodulation Improved Constipation via Modulating Gastrointestinal Hormones and Bile Acids.

Zhenyang Ge, Zhijun Duan, Hang Yang, Shengai Zhang, Shuang Zhang, Lixia Wang, Dong Yang, Xiaoyu Sun, Zhifeng Zhang, Liping Su and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Evidence-based complementary and alternative medicine : eCAM, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Trial
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  10. Article
  11. Elobixibat for the treatment of constipation.Expert review of gastroenterology & hepatology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Zhenyang GeNeurogastroenterology and Motility Center of China-US Cooperation, The Second Department of Gastroenterology, College of Integrative Medicine, The First Affiliated Hospital of Dalian Medical University, No. 222 Zhongshan Road, Dalian, Liaoning 116011, China.ORCID 0000-0001-6535-8634
Zhijun DuanNeurogastroenterology and Motility Center of China-US Cooperation, The Second Department of Gastroenterology, College of Integrative Medicine, The First Affiliated Hospital of Dalian Medical University, No. 222 Zhongshan Road, Dalian, Liaoning 116011, China.ORCID 0000-0001-7976-4959
Hang YangNeurogastroenterology and Motility Center of China-US Cooperation, The Second Department of Gastroenterology, College of Integrative Medicine, The First Affiliated Hospital of Dalian Medical University, No. 222 Zhongshan Road, Dalian, Liaoning 116011, China.ORCID 0000-0002-7235-8162
Shengai ZhangNeurogastroenterology and Motility Center of China-US Cooperation, The Second Department of Gastroenterology, College of Integrative Medicine, The First Affiliated Hospital of Dalian Medical University, No. 222 Zhongshan Road, Dalian, Liaoning 116011, China.ORCID 0000-0002-7679-4412
Shuang ZhangNeurogastroenterology and Motility Center of China-US Cooperation, The Second Department of Gastroenterology, College of Integrative Medicine, The First Affiliated Hospital of Dalian Medical University, No. 222 Zhongshan Road, Dalian, Liaoning 116011, China.ORCID 0000-0003-3401-7321
Lixia WangNeurogastroenterology and Motility Center of China-US Cooperation, The Second Department of Gastroenterology, College of Integrative Medicine, The First Affiliated Hospital of Dalian Medical University, No. 222 Zhongshan Road, Dalian, Liaoning 116011, China.
Dong YangNeurogastroenterology and Motility Center of China-US Cooperation, The Second Department of Gastroenterology, College of Integrative Medicine, The First Affiliated Hospital of Dalian Medical University, No. 222 Zhongshan Road, Dalian, Liaoning 116011, China.ORCID 0000-0003-1252-9190
Xiaoyu SunNeurogastroenterology and Motility Center of China-US Cooperation, The Second Department of Gastroenterology, College of Integrative Medicine, The First Affiliated Hospital of Dalian Medical University, No. 222 Zhongshan Road, Dalian, Liaoning 116011, China.
Zhifeng ZhangNeurogastroenterology and Motility Center of China-US Cooperation, The Second Department of Gastroenterology, College of Integrative Medicine, The First Affiliated Hospital of Dalian Medical University, No. 222 Zhongshan Road, Dalian, Liaoning 116011, China.ORCID 0000-0002-8427-8821
Liping SuNeurogastroenterology and Motility Center of China-US Cooperation, The Second Department of Gastroenterology, College of Integrative Medicine, The First Affiliated Hospital of Dalian Medical University, No. 222 Zhongshan Road, Dalian, Liaoning 116011, China.ORCID 0000-0001-8358-2090
Hong ZhuClinical Laboratory, The First Affiliated Hospital of Dalian Medical University, No. 222 Zhongshan Road, Dalian, Liaoning 116011, China.ORCID 0000-0003-2090-1343
Dongdong ZhouClinical Laboratory, The First Affiliated Hospital of Dalian Medical University, No. 222 Zhongshan Road, Dalian, Liaoning 116011, China.
Bojia LiuNeurogastroenterology and Motility Center of China-US Cooperation, The Second Department of Gastroenterology, College of Integrative Medicine, The First Affiliated Hospital of Dalian Medical University, No. 222 Zhongshan Road, Dalian, Liaoning 116011, China.
Honggang ShiNeurogastroenterology and Motility Center of China-US Cooperation, The Second Department of Gastroenterology, College of Integrative Medicine, The First Affiliated Hospital of Dalian Medical University, No. 222 Zhongshan Road, Dalian, Liaoning 116011, China.ORCID 0000-0001-9822-2258
Jun YuNeurogastroenterology and Motility Center of China-US Cooperation, The Second Department of Gastroenterology, College of Integrative Medicine, The First Affiliated Hospital of Dalian Medical University, No. 222 Zhongshan Road, Dalian, Liaoning 116011, China.ORCID 0000-0003-0286-1632
Hui YangNeurogastroenterology and Motility Center of China-US Cooperation, The Second Department of Gastroenterology, College of Integrative Medicine, The First Affiliated Hospital of Dalian Medical University, No. 222 Zhongshan Road, Dalian, Liaoning 116011, China.ORCID 0000-0001-9416-7829
Qingyong ChangThe Second Department of Neurosurgery, Affiliated Zhongshan Hospital of Dalian University, No. 6 Jiefang Street, Dalian, Liaoning 116001, China.ORCID 0000-0002-1206-2423
Nina ZhangDepartment of Gastroenterology, Nanjing Drum Tower Hospital, No. 321 Zhongshan Road, Nanjing, Jiangsu 210008, China.ORCID 0000-0002-6857-1091
Dongsheng WuThe School of Engineering and Materials Science, Queen Mary, University of London, London E1 4NS, UK.ORCID 0000-0002-8745-2426
Jiande D Z ChenDivision of Gastroenterology and Hepatology, Johns Hopkins Center for Neurogastroenterology, Baltimore, MD 21224, USA.ORCID 0000-0002-0191-5697

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aims to investigate the role of transcutaneous neuromodulation (TN) on the regulation of gastrointestinal hormones and bile acids in patients with functional constipation (FC). Twenty FC patients were treated with TN for four weeks. The effects of TN on symptoms were evaluated by questionnaires. Plasma levels of serotonin (5-HT), motilin, somatostatin, and vasoactive intestinal peptide (VIP) were measured by ELISA and 12 individual bile acids assayed by liquid chromatography tandem mass spectrometry. Results were as follows. (1) TN treatment increased the frequency of spontaneous bowel movement, improved the Bristol Stool Score, and reduced Patient Assessment of Constipation Symptom score and Patient Assessment of Constipation Quality of Life score. (2) FC patients showed decreased plasma levels of 5-HT, motilin, and VIP and an increased plasma level of somatostatin (

Identifiers

PMID29853946
PMCPMC5949156

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.