Evidence map›Paper›PMID 29853941›Full record

ArticleKorean journal of pediatrics2018

Clinical implications in laboratory parameter values in acute Kawasaki disease for early diagnosis and proper treatment.

Yu-Mi Seo, Hyun-Mi Kang, Sung-Churl Lee, Jae-Won Yu, Hong-Ryang Kil, Jung-Woo Rhim, Ji-Whan Han, Kyung-Yil Lee

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Korean journal of pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Yu-Mi SeoDepartment of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Hyun-Mi KangDepartment of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Sung-Churl LeeDepartment of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Jae-Won YuDepartment of Pediatrics, Chungnam National University Hospital, School of Medicine, Chungnam National University, Daejeon, Korea.
Hong-Ryang KilDepartment of Pediatrics, Chungnam National University Hospital, School of Medicine, Chungnam National University, Daejeon, Korea.
Jung-Woo RhimDepartment of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Ji-Whan HanDepartment of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Kyung-Yil LeeDepartment of Pediatrics, College of Medicine, The Catholic University of Korea, Seoul, Korea.ORCID https://orcid.org/0000-0001-6510-1580
Catholic University of Korea · KRThe Catholic University of Korea Daejeon St. Mary's Hospital · KRChungnam National University Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aimed to analyse laboratory values according to fever duration, and evaluate the relationship across these values during the acute phase of Kawasaki disease (KD) to aid in the early diagnosis for early-presenting KD and incomplete KD patients.

methodsClinical and laboratory data of patients with KD (n=615) were evaluated according to duration of fever at presentation, and were compared between patients with and without coronary artery lesions (CALs). For evaluation of the relationships across laboratory indices, patients with a fever duration of 5 days or 6 days were used (n=204).

resultsThe mean fever duration was 6.6±2.3 days, and the proportions of patients with CALs was 19.3% (n=114). C-reactive proteins (CRPs) and neutrophil differential values were highest and hemoglobin, albumin, and lymphocyte differential values were lowest in the 6-day group. Patients with CALs had longer total fever duration, higher CRP and neutrophil differential values and lower hemoglobin and albumin values compared to patients without CALs. CRP, albumin, neutrophil differential, and hemoglobin values at the peak inflammation stage of KD showed positive or negative correlations each other.

conclusionThe severity of systemic inflammation in KD was reflected in the laboratory values including CRP, neutrophil differential, albumin, and hemoglobin. Observing changes in these laboratory parameters by repeated examinations prior to the peak of inflammation in acute KD may aid in diagnosis of early-presenting KD patients.

Indexed as

AlbuminCoronary artery lesionC-reactive proteinHemoglobinKawasaki disease

Identifiers

PMID29853941
PMCPMC5976566
OpenAlexW2804914058

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.