Evidence map›Paper›PMID 29853915›Full record

ArticleStem cells international2018

Knitted 3D Scaffolds of Polybutylene Succinate Support Human Mesenchymal Stem Cell Growth and Osteogenesis.

Miina Ojansivu, Laura Johansson, Sari Vanhatupa, Ilmari Tamminen, Markus Hannula, Jari Hyttinen, Minna Kellomäki, Susanna Miettinen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Miina OjansivuAdult Stem Cell Research Group, Faculty of Medicine and Life Sciences and BioMediTech Institute, University of Tampere, Tampere, Finland.ORCID 0000-0002-5493-3530
Laura JohanssonLaboratory of Biomaterials and Tissue Engineering, Faculty of Biomedical Science and Engineering and BioMediTech Institute, Tampere University of Technology, Tampere, Finland.
Sari VanhatupaAdult Stem Cell Research Group, Faculty of Medicine and Life Sciences and BioMediTech Institute, University of Tampere, Tampere, Finland.
Ilmari TamminenThe Computational Biophysics and Imaging Group, Faculty of Biomedical Science and Engineering and BioMediTech Institute, Tampere University of Technology, Tampere, Finland.
Markus HannulaThe Computational Biophysics and Imaging Group, Faculty of Biomedical Science and Engineering and BioMediTech Institute, Tampere University of Technology, Tampere, Finland.
Jari HyttinenThe Computational Biophysics and Imaging Group, Faculty of Biomedical Science and Engineering and BioMediTech Institute, Tampere University of Technology, Tampere, Finland.
Minna KellomäkiLaboratory of Biomaterials and Tissue Engineering, Faculty of Biomedical Science and Engineering and BioMediTech Institute, Tampere University of Technology, Tampere, Finland.
Susanna MiettinenAdult Stem Cell Research Group, Faculty of Medicine and Life Sciences and BioMediTech Institute, University of Tampere, Tampere, Finland.ORCID 0000-0002-0647-9556

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polybutylene succinate (PBS) is a biodegradable polyester with better processability and different mechanical properties compared to polylactides (PLAs), the most commonly used synthetic polymers in tissue engineering (TE). Since only few studies have evaluated PBS-containing materials for bone TE, we prepared PLA-PBS blends and analyzed material properties as well as cell attachment, proliferation, and osteogenic differentiation of human mesenchymal stem cells (hMSCs) on scaffolds. In addition to PLA, PBS, and PLA-PBS blends, PLA-polycaprolactone and PLA-poly(trimethylene carbonate) blends were evaluated. Polymer fibers were prepared using melt spinning. Pure PBS was observed to have the highest crystallinity and strain at break compared to the tougher PLA and PLA blends. No degradation occurred during the 4-week hydrolysis in either of the materials. Knitted and rolled scaffolds were manufactured, seeded with hMSCs, and cultured for 27 days. Human MSC viability was good on all the materials, but cell spreading along the fibers was only detected in PBS-containing scaffolds. They also induced the strongest proliferative response and osteogenic differentiation, which diminished with decreasing PBS content. Based on these results, PBS is superior to PLA with respect to hMSC attachment, proliferation, and osteogenesis. This encourages utilizing PBS-based biomaterials more widely in bone TE applications.

Identifiers

PMID29853915
PMCPMC5964421

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.