ArticleInternational journal of endocrinology2018
Changes in Body Compositions and Basal Metabolic Rates during Treatment of Graves' Disease.
Article in International journal of endocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06921304 (BASE-DIET), which is not on this map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
BASE-DIET: a Randomized Clinical Trial to Examine the Impact of a Dietary-nutritional Intervention on Body Weight Recovery, Metabolic Parameters, and Body Composition in Patients With a New Diagnosis of Graves' Disease
Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Brown adipose tissues mediate the metabolism of branched chain amino acids during the transitioning from hyperthyroidism to euthyroidism (TRIBUTE).Scientific reports · 2022Trial
- Women with Graves' Disease Have Altered Proximal Hip Geometry, Trabecular Bone Score and Body Composition Parameters: A Case-Control Study from Southern India.Calcified tissue international · 2026Article
- Severity of thyrotoxicosis is a risk factor for excessive weight gain in treated hyperthyroidism.European thyroid journal · 2025Article
- Estimation of kidney function in Graves' disease using creatinine and cystatin C.Endocrine connections · 2025Article
- Chronic thyrotoxic myopathy development is associated with thyroid hormone sensitivity index, predicted by lower-limb fatigue and the squat-up test.Scientific reports · 2024Article
- Alterations in Body Weight and Composition in Patients With Graves' Disease Treated with Total Thyroidectomy.Cureus · 2024Article
- Article
- Effects of levothyroxine substitution therapy on hunger and food intake in individuals with hypothyroidism.Endocrine connections · 2023Article
- Levothyroxine therapy, calculated deiodinases activity and basal metabolic rate in obese or nonobese patients after total thyroidectomy for differentiated thyroid cancer, results of a retrospective observational study.Endocrinology, diabetes & metabolism · 2023Observational
- Weight Gain and Body Composition Changes during the Transition of Thyroid Function in Patients with Graves' Disease Undergoing Radioiodine Treatment.International journal of endocrinology · 2022Article
- An unusual finding of giant fat-rich retroperitoneal masses in a patient with Graves' disease.Oxford medical case reports · 2020Article
- Impact of thyroid hormones on asthma in older adults.The Journal of international medical research · 2019Article
- Thyroid Hormone Action and Energy Expenditure.Journal of the Endocrine Society · 2019Review
- THYROTOXICOSIS AND ITS RELATION TO SARCOPENIA, MUSCLE STRENGTH, MUSCLE MASS AND PHYSICAL PERFORMANCE.Acta endocrinologica (Bucharest, Romania : 2005)Article
- Serum Fibroblast Growth Factor 21 Levels in Patients with Hyperthyroidism and its Association with Body Fat Percentage.Indian journal of endocrinology and metabolismArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesBecause thyroid hormone is an important determinant of body weight and basal metabolic rate, we investigated the changes in the basal metabolic rate and body composition sequentially after treatment for Graves' disease.
methodsA prospective cohort study was performed with six women newly diagnosed with Graves' disease. During a 52-week treatment of methimazole, body composition, resting respiratory expenditure (REE), and handgrip strength were measured consecutively.
resultsAfter methimazole treatment, body weight was initially increased (0-8 weeks), subsequently plateaued (8-24 weeks), and gradually decreased in the later period (24-52 weeks) despite the decreased food intake. The measured REE was 40% higher than the predicted REE at baseline, and it gradually decreased after treatment. REE positively correlated with thyroid hormone levels, peripheral deiodinase activity, and thyroid's secretory capacity. Body compositional analyses showed that the fat mass increased during an earlier period (4-12 weeks), while the lean mass increased significantly during the later period (26-52 weeks). Consistent with the lean mass changes, muscle strength also significantly increased during the later period.
conclusionsTreatment of Graves' disease increased body weight and fat mass transiently with decreased REE. However, long-term compositional changes moved in a beneficial direction increasing lean mass and reinforcing muscle strength, following decreasing fat percentages.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.