ArticleInternational journal of endocrinology2018
Metabolic Syndrome and Its Components in Young Adults Conceived by ICSI.
Article in International journal of endocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Infertility treatment and offspring blood pressure-a systematic review and meta-analysis.Human reproduction update · 2025Pooled it
- Metabolic Syndrome in Offspring of Parents with Metabolic Syndrome: A Meta-Analysis.Obesity facts · 2021Pooled it
- Trial
- Effects of assisted reproductive techniques on offspring cardiovascular health: a systematic review and meta-analysis.Journal of assisted reproduction and genetics · 2026Review
- Focus on the endocrine system of children born after reproductive technologies in Kazakhstan.Qatar medical journal · 2025Article
- Metabolic Status and Expression Level of SREBP mRNA and Mir-33 Among Children Conceived by Assisted Reproductive Technology.International journal of genomics · 2025Article
- Altered metabolic profiles in male offspring conceived from intracytoplasmic sperm injection.BMC medicine · 2024Article
- Transcriptomic Signatures of the Foetal Liver and Late Prenatal Development in Vitrified Rabbit Embryos.Veterinary sciences · 2024Article
- Long-term health risk of offspring born from assisted reproductive technologies.Journal of assisted reproduction and genetics · 2024Review
- Frequency, morbidity and equity - the case for increased research on male fertility.Nature reviews. Urology · 2024Review
- Metabolomic Profile of Children Conceived With Medically Assisted Technologies.The Journal of clinical endocrinology and metabolism · 2023Article
- Reproductive outcomes in women and men conceived by assisted reproductive technologies in Norway: prospective registry based study.BMJ medicine · 2023Article
- Conception by fertility treatment and cardiometabolic risk in middle childhood.Fertility and sterility · 2022Article
- Comparison of the cardiometabolic profiles of adolescents conceived through ART with those of a non-ART cohort.Human reproduction (Oxford, England) · 2022Observational
- The Consequences of Assisted Reproduction Technologies on the Offspring Health Throughout Life: A Placental Contribution.Frontiers in cell and developmental biology · 2022Review
- Genetic Factors of Non-Obstructive Azoospermia: Consequences on Patients' and Offspring Health.Journal of clinical medicine · 2021Review
- Effect of Embryo Vitrification on the Steroid Biosynthesis of Liver Tissue in Rabbit Offspring.International journal of molecular sciences · 2020Article
- Health and fertility of ICSI-conceived young men: study protocol.Human reproduction open · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIntracytoplasmic sperm injection (ICSI) conception presents the early embryo with a radically different environment, which may lead to permanent alterations to key cardiometabolic processes. Blood pressure, indicators of insulin resistance, and lipid profiles have previously been studied in offspring born after in vitro fertilisation (IVF) and ICSI, with conflicting findings. Also, results in young adults born after ICSI are lacking.
aimWe investigated if young adult men and women conceived by ICSI more frequently have metabolic syndrome and its individual features in comparison to spontaneously conceived controls.
designCardiometabolic and anthropometric parameters from 126 longitudinally followed young adults conceived by ICSI were compared to those of 133 controls.
resultsAt age 18 years, only 1 of the participants displayed the metabolic syndrome (1 control woman). Mean concentrations of total cholesterol, triglycerides, insulin, HOMA-IR, and blood pressure were comparable between the ICSI conceived and control participants. A higher proportion (19.6%) of men conceived by ICSI had low (<40 mg/dl) HDL cholesterol compared to controls (5.6%).
conclusionsWhile men conceived by ICSI, but not women, had lower mean HDL cholesterol concentrations in comparison to controls, other markers of the metabolic syndrome were not affected by the mode of conception.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.