Evidence map›Paper›PMID 29853882›Full record

ArticleInternational journal of endocrinology2018

Characterization of

Sonja G Karst, Jan Lammer, Salma H Radwan, Hanna Kwak, Paolo S Silva, Stephen A Burns, Lloyd Paul Aiello, Jennifer K Sun

Open access · goldAbstract read
In one paragraph

Article in International journal of endocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Observational
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Looking Ahead: Visual and Anatomical Endpoints in Future Trials of Diabetic Macular Ischemia.Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde · 2021
    Review
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 3 countries.

Sonja G KarstBeetham Eye Institute, Joslin Diabetes Center, Boston, MA, USA.ORCID 0000-0002-8886-131X
Jan LammerBeetham Eye Institute, Joslin Diabetes Center, Boston, MA, USA.
Salma H RadwanBeetham Eye Institute, Joslin Diabetes Center, Boston, MA, USA.
Hanna KwakBeetham Eye Institute, Joslin Diabetes Center, Boston, MA, USA.
Paolo S SilvaBeetham Eye Institute, Joslin Diabetes Center, Boston, MA, USA.
Stephen A BurnsSchool of Optometry, Indiana University, Bloomington, IN, USA.
Lloyd Paul AielloBeetham Eye Institute, Joslin Diabetes Center, Boston, MA, USA.
Jennifer K SunBeetham Eye Institute, Joslin Diabetes Center, Boston, MA, USA.ORCID 0000-0003-0915-6303
Joslin Diabetes Center · USIndiana University Bloomington · US

Funding

SPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI JEAN E. SCHAFFER · 1986 to 2026
$50.5M
Adaptive Optics Imaging of Human Retinal Vascular Structure and FunctionR01EY024315 · NEI · TRUSTEES OF INDIANA UNIVERSITY · PI BURNS, STEPHEN A · 2015 to 2024
$4.3M
Core Support for Vision Research at Indiana UniversityP30EY019008 · NEI · TRUSTEES OF INDIANA UNIVERSITY · PI BURNS, STEPHEN A · 2009 to 2013
$2.1M
Long Stroke Wavefront Correctors for Retinal ImagingR44EY016295 · NEI · BOSTON MICROMACHINES CORPORATION · PI BIERDEN, PAUL ARTHUR · 2007 to 2013
$2.1M
Predicting Outcomes & Anti-VEGF Response in Diabetic Eyes by Adaptive Optics SLOR01EY024702 · NEI · JOSLIN DIABETES CENTER · PI SUN, JENNIFER KATHERINE · 2014 to 2018
$1.7M
NEI NIH HHS P30 EY019008NEI NIH HHS R01 EY024315NEI NIH HHS R01 EY024702NEI NIH HHS R44 EY016295NIDDK NIH HHS P30 DK036836
6 · The paper itself

Abstract

purposeTo characterize hallmark diabetic retinopathy (DR) lesions utilizing adaptive optics scanning laser ophthalmoscopy (AOSLO) and to compare AOSLO findings with those on standard imaging techniques.

methodsCross-sectional study including 35 eyes of 34 study participants. AOSLO confocal and multiply scattered light (MSL) imaging were performed in eyes with DR. Color fundus photographs (CF), infrared images of the macula (Spectralis, Heidelberg), and Spectralis spectral domain optical coherence tomography SDOCT B-scans of each lesion were obtained and registered to corresponding AOSLO images.

main outcome measuresIndividual lesion characterization by AOSLO imaging. AOSLO appearance was compared with CF and SDOCT imaging.

resultsCharacterized lesions encompassed 52 microaneurysms (MA), 20 intraretinal microvascular abnormalities (IRMA), 7 neovascularization (NV), 11 hard exudates (HE), 5 dot/blot hemorrhages (HEM), 4 cotton wool spots (CWS), and 14 intraretinal cysts. AOSLO allowed assessment of perfusion in vascular lesions and enabled the identification of vascular lesions that could not be visualized on CF or SDOCT.

conclusionsAOSLO imaging provides detailed, noninvasive

Identifiers

PMID29853882
PMCPMC5954931
OpenAlexW2801632546

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.