Evidence map›Paper›PMID 29853851›Full record

ArticleNeural plasticity2018

Cardiac Arrest Induces Ischemic Long-Term Potentiation of Hippocampal CA1 Neurons That Occludes Physiological Long-Term Potentiation.

James E Orfila, Nicole McKinnon, Myriam Moreno, Guiying Deng, Nicholas Chalmers, Robert M Dietz, Paco S Herson, Nidia Quillinan

Open access · goldAbstract read
In one paragraph

Article in Neural plasticity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. TRPM2 and CaMKII Signaling Drives Excessive GABAergic Synaptic Inhibition Following Ischemia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
  4. Resveratrol Preconditioning Protects Against Ischemia-Induced Synaptic Dysfunction and Cofilin Hyperactivation in the Mouse Hippocampal Slice.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023
    Article
  5. Review
  6. Effects of Exercise on Long-Term Potentiation in Neuropsychiatric Disorders.Advances in experimental medicine and biology · 2020
    Review
  7. Immediate and delayed decrease of long term potentiation and memory deficits after neonatal intermittent hypoxia.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2019
    Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

James E OrfilaNeuronal Injury Program, Department of Anesthesiology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
Nicole McKinnonDepartment of Pediatrics, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
Myriam MorenoNeuronal Injury Program, Department of Anesthesiology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
Guiying DengDepartment of Pharmacology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
Nicholas ChalmersNeuronal Injury Program, Department of Anesthesiology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
Robert M DietzDepartment of Pediatrics, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
Paco S HersonNeuronal Injury Program, Department of Anesthesiology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.
Nidia QuillinanNeuronal Injury Program, Department of Anesthesiology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0002-5708-8395
University of Colorado Anschutz Medical Campus · US

Funding

Sex Steroids and Brain Outcome from Cardiac Arrest/Cardiopulmonary ResuscitationR01NS046072 · NINDS · UNIVERSITY OF COLORADO DENVER · PI HERSON, PACO S, QUILLINAN, NIDIA · 2002 to 2024
$7.0M
CaMKII in global cerebral ischemiaR01NS080851 · NINDS · UNIVERSITY OF COLORADO DENVER · PI BAYER, K. ULRICH, HERSON, PACO S · 2013 to 2017
$2.1M
Targeting TRPM2 channels to improve synaptic and cognitive function after cerebral ischemiaR01NS092645 · NINDS · UNIVERSITY OF COLORADO DENVER · PI HERSON, PACO S · 2016 to 2020
$1.7M
NINDS NIH HHS R01 NS046072NINDS NIH HHS R01 NS080851NINDS NIH HHS R01 NS092645
6 · The paper itself

Abstract

Ischemic long-term potentiation (iLTP) is a form of synaptic plasticity that occurs in acute brain slices following oxygen-glucose deprivation.

Indexed as

Long-Term PotentiationAnimalsBrain IschemiaCA1 Region, HippocampalHeart ArrestLong-Term Synaptic DepressionMaleMice, Inbred C57BLNeuronsReceptors, AMPAReceptors, AMPA

Identifiers

PMID29853851
PMCPMC5944194
OpenAlexW2802692844

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.