Evidence map›Paper›PMID 29853846›Full record

ArticleNeural plasticity2018

Danshen-Honghua Ameliorates Stress-Induced Menopausal Depression in Rats.

Simeng Gu, Yao Ma, Kemin Ge, Ruifang Nie, Erxi Wu, Yang Li

Open access · goldAbstract read
In one paragraph

Article in Neural plasticity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Compatibility of ingredients of Danshen (RadixExperimental and therapeutic medicine · 2021
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Simeng GuDepartment of Psychology, Jiangsu University Medical School, Zhenjiang 212013, China.ORCID 0000-0002-7018-8075
Yao MaSchool of Life Science, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Kemin GeSchool of Life Science, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Ruifang NieSchool of Life Science, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Erxi WuDepartment of Neurosurgery, Baylor Scott & White Health, Temple, TX 76358, USA.
Yang LiSchool of Life Science, Nanjing University of Chinese Medicine, Nanjing 210023, China.ORCID 0000-0001-7929-6331
Nanjing University of Chinese Medicine · CNJiangsu University · CNTemple College · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Previously, we have shown that Danshen-Honghua (DSHH) for cognitive deficits after ischemia induced impairments of the hippocampus. Here, we investigate the effects of DSHH on stress-induced depression in menopausal rats. Methods: A rat model with menopausal depression was established with bilateral ovariectomies in female SD rats followed by chronic mild stress treatment for 21 days. 40 rats were randomly divided into the sham surgery group (sham surgery and no stress treatment), surgery group (surgery with no stress treatment), surgery/stress group (surgery and stress treatment), fluoxetine group (2.4 mg·kg Results: The results of open-field locomotor scores, sucrose intake in both the fluoxetine group and DSHH group, were significantly higher than those of the surgery/stress group ( Conclusion: DSHH can ameliorate stress-induced depressed syndromes in the surgery/stressed rats via regulating LH and FSH levels as well as monoamine levels.

Indexed as

AnimalsAntidepressive AgentsBehavior, AnimalBiogenic MonoaminesCarthamus tinctoriusDepressionDrugs, Chinese HerbalFemaleGonadal Steroid HormonesMenopauseRats, Sprague-DawleySalvia miltiorrhizaStress, PsychologicalAntidepressive AgentsBiogenic Monoaminesdan-shen root extractDrugs, Chinese HerbalGonadal Steroid HormonesHonghua extract, Carthamus tinctorius

Identifiers

PMID29853846
PMCPMC5960543
OpenAlexW2802997101

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.