Evidence map›Paper›PMID 29853808›Full record

ArticleContrast media & molecular imaging2018

Positron Emission Tomography Imaging Reveals an Importance of Saturable Liver Uptake Transport for the Pharmacokinetics of Metoclopramide.

Fabien Caillé, Sébastien Goutal, Solène Marie, Sylvain Auvity, Salvatore Cisternino, Bertrand Kuhnast, Géraldine Pottier, Nicolas Tournier

Open access · hybridAbstract read
In one paragraph

Article in Contrast media & molecular imaging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Impact of P-Glycoprotein Function on the Brain Kinetics of the Weak SubstrateJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2019
    Trial
  2. Designing a Small Molecule for PET Radiotracing: [Molecules (Basel, Switzerland) · 2025
    Review
  3. Performance and Sensitivity of [Molecular pharmaceutics · 2024
    Article
  4. [Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
  5. Article
  6. Article
  7. Comparative vulnerability of PET radioligands to partial inhibition of P-glycoprotein at the blood-brain barrier: A criterion of choice?Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
    Article
  8. Article
  9. Imaging P-Glycoprotein Induction at the Blood-Brain Barrier of a β-Amyloidosis Mouse Model withJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2020
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Fabien CailléImagerie Moléculaire in Vivo, IMIV, CEA, Inserm, CNRS, University of Paris-Sud, Université Paris Saclay, CEA-SHFJ, Orsay 91400, France.
Sébastien GoutalImagerie Moléculaire in Vivo, IMIV, CEA, Inserm, CNRS, University of Paris-Sud, Université Paris Saclay, CEA-SHFJ, Orsay 91400, France.
Solène MarieImagerie Moléculaire in Vivo, IMIV, CEA, Inserm, CNRS, University of Paris-Sud, Université Paris Saclay, CEA-SHFJ, Orsay 91400, France.
Sylvain AuvityImagerie Moléculaire in Vivo, IMIV, CEA, Inserm, CNRS, University of Paris-Sud, Université Paris Saclay, CEA-SHFJ, Orsay 91400, France.
Salvatore CisterninoVariabilité de Réponse aux Psychotropes, UMR-S 1144, Inserm, Université Paris Descartes, Université Paris Diderot, Paris 75006, France.
Bertrand KuhnastImagerie Moléculaire in Vivo, IMIV, CEA, Inserm, CNRS, University of Paris-Sud, Université Paris Saclay, CEA-SHFJ, Orsay 91400, France.
Géraldine PottierImagerie Moléculaire in Vivo, IMIV, CEA, Inserm, CNRS, University of Paris-Sud, Université Paris Saclay, CEA-SHFJ, Orsay 91400, France.
Nicolas TournierImagerie Moléculaire in Vivo, IMIV, CEA, Inserm, CNRS, University of Paris-Sud, Université Paris Saclay, CEA-SHFJ, Orsay 91400, France.ORCID 0000-0002-0755-2030
Université Paris-Sud · FRDélégation Paris 5 · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Positron emission tomography (PET) imaging using [

Indexed as

AnimalsArea Under CurveATP Binding Cassette Transporter, Subfamily B, Member 1Biological TransportCarbon RadioisotopesLiverMetabolic Clearance RateMetoclopramidePositron-Emission TomographyRatsATP Binding Cassette Transporter, Subfamily B, Member 1Carbon RadioisotopesMetoclopramide

Identifiers

PMID29853808
PMCPMC5964550
OpenAlexW2800419196

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.