Evidence map›Paper›PMID 29853803›Full record

ArticleContrast media & molecular imaging2018

Thallium Labeled Citrate-Coated Prussian Blue Nanoparticles as Potential Imaging Agent.

Krisztián Szigeti, Nikolett Hegedűs, Kitti Rácz, Ildikó Horváth, Dániel S Veres, Dávid Szöllősi, Ildikó Futó, Károly Módos, Tamás Bozó, Kinga Karlinger and 7 more

Abstract read
In one paragraph

Article in Contrast media & molecular imaging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
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  4. Rational nanoparticle design: Optimization using insights from experiments and mathematical models.Journal of controlled release : official journal of the Controlled Release Society · 2023
    Review
  5. Article
  6. [MnNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2021
    Article
  7. Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Krisztián SzigetiDepartment of Biophysics and Radiation Biology, Semmelweis University, Budapest 1094, Hungary.ORCID 0000-0002-0828-9828
Nikolett HegedűsDepartment of Biophysics and Radiation Biology, Semmelweis University, Budapest 1094, Hungary.ORCID 0000-0003-1122-1872
Kitti RáczDepartment of Biophysics and Radiation Biology, Semmelweis University, Budapest 1094, Hungary.
Ildikó HorváthDepartment of Biophysics and Radiation Biology, Semmelweis University, Budapest 1094, Hungary.
Dániel S VeresDepartment of Biophysics and Radiation Biology, Semmelweis University, Budapest 1094, Hungary.
Dávid SzöllősiDepartment of Biophysics and Radiation Biology, Semmelweis University, Budapest 1094, Hungary.
Ildikó FutóDepartment of Biophysics and Radiation Biology, Semmelweis University, Budapest 1094, Hungary.
Károly MódosDepartment of Biophysics and Radiation Biology, Semmelweis University, Budapest 1094, Hungary.
Tamás BozóDepartment of Biophysics and Radiation Biology, Semmelweis University, Budapest 1094, Hungary.
Kinga KarlingerDepartment of Radiology and Oncotherapy, Semmelweis University, Budapest 1094, Hungary.
Noémi KovácsCROmed Translational Research Centers, Budapest 1047, Hungary.
Zoltán VargaDepartment of Biophysics and Radiation Biology, Semmelweis University, Budapest 1094, Hungary.ORCID 0000-0002-5741-2669
Magor BabosMediso Medical Imaging Systems Ltd., Budapest 1022, Hungary.
Ferenc BudánCROmed Translational Research Centers, Budapest 1047, Hungary.
Parasuraman PadmanabhanLee Kong Chian School of Medicine, Nanyang Technological University, Singapore.ORCID 0000-0003-4112-4600
Balázs GulyásLee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
Domokos MáthéDepartment of Biophysics and Radiation Biology, Semmelweis University, Budapest 1094, Hungary.ORCID 0000-0001-7343-0413

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The aim of this study was to develop and characterize a nanoparticle-based image-contrast platform which is biocompatible, chemically stable, and accessible for radiolabeling with Methods: The physical properties of citrate-coated Prussian blue nanoparticles (PBNPs) (iron(II);iron(III);octadecacyanide) doped with Results: PBNP accumulation peaked at 2 hours after injection predominantly in the kidneys and the liver followed by a gradual decrease in activity in later time points. Conclusion: We synthetized, characterized, and radiolabeled a Prussian blue-based nanoparticle platform for contrast material applications. Its in vivo radiochemical stability and biodistribution open up the way for further diagnostic applications.

Indexed as

FerrocyanidesAnimalsCitric AcidContrast MediaDrug StabilityMagnetic Resonance ImagingMiceMice, Inbred C57BLNanoparticlesRadiopharmaceuticalsThalliumTissue DistributionTomography, Emission-Computed, Single-PhotonCitric AcidContrast Mediaferric ferrocyanideFerrocyanidesRadiopharmaceuticalsThallium

Identifiers

PMID29853803
PMCPMC5944205

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.