Evidence map›Paper›PMID 29853786›Full record

ArticleMediators of inflammation2018

Characterization of Site-Specific Phosphorylation of NF-

Haoshen Shi, Elizabeth A Berger

Open access · goldAbstract read
In one paragraph

Article in Mediators of inflammation, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. Inflammation, diabetic foot and related treatments.Frontiers in endocrinology · 2025
    Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Exploring NFJournal of public health in Africa · 2022
    Article
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  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Haoshen ShiDepartment of Anatomy & Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Elizabeth A BergerDepartment of Anatomy & Cell Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA.ORCID 0000-0001-5371-1170
Wayne State University · US

Funding

VISION RESEARCH--COREP30EY004068 · NEI · WAYNE STATE UNIVERSITY · PI LINDA D HAZLETT · 1985 to 2026
$13.2M
VIP and Disease Resolution of Bacterial-Induced Ocular InfectionR01EY023226 · NEI · WAYNE STATE UNIVERSITY · PI BERGER, ELIZABETH · 2014 to 2017
$1.5M
NEI NIH HHS P30 EY004068NEI NIH HHS R01 EY023226
6 · The paper itself

Abstract

backgroundInflammation is an important contributor to the pathogenesis of diabetic retinopathy (DR). NF-

methodsPhosphorylation of NF-

resultsHG exposure resulted in differential phosphorylation of p65 subunit sites between HREC and Müller cells. Proinflammatory cytokines further increased phosphorylation of these sites and additional sites that were not altered in HG. In contrast, IL-4 exhibited a suppressive effect on the phosphorylation of p65 sites in both cell types and promoted I

conclusionThe current study is the first to characterize HG-induced NF-

Indexed as

Blotting, WesternCells, CulturedEnzyme-Linked Immunosorbent AssayGene Expression RegulationGlucoseHumansInterleukin-1betaInterleukin-4PhosphorylationRetinaReverse Transcriptase Polymerase Chain ReactionTranscription Factor RelATumor Necrosis Factor-alphaGlucoseInterleukin-1betaInterleukin-4Transcription Factor RelATumor Necrosis Factor-alpha

Identifiers

PMID29853786
PMCPMC5944204
OpenAlexW2801909890

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.