Evidence map›Paper›PMID 29853737›Full record

Trial reportWorld journal of gastroenterology2018

Regulatory polymorphism of CXCL10 rs1439490 in seronegative occult hepatitis C virus infection.

Xu Wang, Song Wang, Zhen-Hua Liu, Wen-Qian Qi, Qian Zhang, Yong-Gui Zhang, De-Rong Sun, Yan Xu, Hong-Guang Wang, Zhong-Xie Li and 4 more

Open access · hybridAbstract readClinical TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in World journal of gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Xu WangDepartment of Digestive, China-Japan Union Hospital Affiliated to Jilin University, Changchun 130033, Jilin Province, China.
Song WangDepartment of Urology, First Hospital Affiliated to Jilin University, Changchun 130000, Jilin Province, China.
Zhen-Hua LiuDepartment of Digestive, China-Japan Union Hospital Affiliated to Jilin University, Changchun 130033, Jilin Province, China.
Wen-Qian QiDepartment of Digestive, China-Japan Union Hospital Affiliated to Jilin University, Changchun 130033, Jilin Province, China.
Qian ZhangDepartment of Digestive, China-Japan Union Hospital Affiliated to Jilin University, Changchun 130033, Jilin Province, China.
Yong-Gui ZhangDepartment of Digestive, China-Japan Union Hospital Affiliated to Jilin University, Changchun 130033, Jilin Province, China.
De-Rong SunDepartment of Infectious Disease, the Fourth Affiliated University of Harbin Medical University, Harbin 150001, Heilongjiang Province, China.
Yan XuDepartment of Digestive, China-Japan Union Hospital Affiliated to Jilin University, Changchun 130033, Jilin Province, China.
Hong-Guang WangDepartment of Digestive, People's Hospital of Jilin City, Changchun 132000, Jilin Province, China.
Zhong-Xie LiDepartment of Digestive, People's Hospital of Hunchun City, Hunchun 133300, Jilin Province, China.
Xian-Ling CongDepartment of Pathology, China-Japan Union Hospital Affiliated to Jilin University, Changchun 130033, Jilin Province, China.
Ping ZhaoDepartment of Digestive, China-Japan Union Hospital Affiliated to Jilin University, Changchun 130033, Jilin Province, China.
Chang-Yu ZhouDepartment of Digestive, China-Japan Union Hospital Affiliated to Jilin University, Changchun 130033, Jilin Province, China.
Jiang-Bin WangDepartment of Digestive, China-Japan Union Hospital Affiliated to Jilin University, Changchun 130033, Jilin Province, China. zrlwangjb@163.com.
Jilin University · CNPeople 's Hospital of Jilin Province · CNXian Yang Central Hospital · CNDaqing City People's Hospital · CNFirst Affiliated Hospital of Chinese PLA General Hospital · CNHarbin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo examine the relationship between the single nucleotide polymorphism CXCL10 rs1439490 and seronegative occult hepatitis C virus (HCV) infection (OCI).

methodsOne hundred and three cases of seronegative OCI and 155 cases of seropositive chronic HCV infection (CHC) were diagnosed at five Liver Centers in Northeastern China, from 2012 to 2016. CXCL10 rs1439490, rs1440802, and IL-28B rs12979860 were analyzed by sequencing. Serum CXCL10 was measured by ELISA. Intrahepatic CXCL10 was determined by quantitative PCR and immunohistochemical semi-quantitative scoring. Liver necroinflammation and fibrosis were scored according to the METAVIR system.

resultsCXCL10 rs1439490 G/G was more prevalent in OCI patients (

conclusionCXCL10 rs1439490 G/G is positively associated with OCI in HCV infection and antiviral outcome.

Indexed as

AdultAntiviral AgentsBiopsyChemokine CXCL10ChinaFemaleHepacivirusHepatitis C, ChronicHumansInterferon-alphaInterferon LambdaInterferonsInterleukinsLiverLiver CirrhosisLiver Function TestsAntiviral AgentsChemokine CXCL10CXCL10 protein, humanInterferon-alphaInterferon Lambdainterferon-lambda, humanInterferonsInterleukinspeginterferon alfa-2aPolyethylene GlycolsRecombinant ProteinsRibavirinRNA, ViralCXCL10Occult hepatitis C virus infectionrs1439490Single nucleotide polymorphisms

Identifiers

PMID29853737
PMCPMC5974581
OpenAlexW2806729015

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.