ArticleCancer discovery2018
Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer.
4 registry-linked trialsOpen access · greenAbstract read
In one paragraph
Article in Cancer discovery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 692 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
692citing papers in PubMed, 2 pooled it
39.3field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
MicroOrganoSphere Drug Screen to Lead Care (MODEL) Precision Oncology Pilot Trial in Colorectal Cancer (CRC)
Pharmacotyping of Patient-derived Pancreatic Cancer Organoids From Endoscopic Ultrasound-guided Biopsy as a Tool for Predicting Oncological Response
Patient-derived Organoid Generation in Pancreatic Cancer: a Single Centre, Open-label, Single Arm Feasibility Study
Exploring the Application of 3D Bioprinting Technology in Constructing Preclinical Models of Pancreatic Cancer for Drug Sensitivity Testing and Its Significance in Personalized Treatment
Who cites it
692 citing papers in PubMed, 2 syntheses or guidelines pooled it, 1,064 citations in OpenAlex.
- Organoids in translation: a bench-to-bedside framework for pancreatic cancer precision medicine.Journal of translational medicine · 2026Pooled it
- A systematic review on the culture methods and applications of 3D tumoroids for cancer research and personalized medicine.Cellular oncology (Dordrecht, Netherlands) · 2025Pooled it
- A Phase III Randomized Trial of Integrated Genomics and Avatar Models for Personalized Treatment of Pancreatic Cancer: The AVATAR Trial.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025Trial
- Stress-specific 14-3-3-client modules in digestive cancers: an evidence-graded review of adaptive survival and therapy resistance.Cancer biology & therapy · 2026Review
- Article
- Patient-Derived Organoids in Functional Precision Oncology: Tumor Modeling, Drug-Response Prediction, and Clinical Translation.Cell biochemistry and function · 2026Review
- Review
- Article
- Global research trends in traditional and complementary medicine for cancer supportive care: a bibliometric analysis (2000-2025).Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Review
- A pancreatic cancer organoid-macrophage co-culture using starPEG-heparin hydrogel deciphers tumor-immune cell interactions.NPJ precision oncology · 2026Article
- Article
- Emerging organoids and organoids-on-chip platforms for translational development of antibody‒drug conjugates and next-generation bioconjugates.Acta pharmaceutica Sinica. B · 2026Review
- Induced pluripotent stem cells from discovery to translation.Nature medicine · 2026Review
- Dual-oxygen pancreatic cancer organoids recapitulate basal-classical heterogeneity validated by spatial transcriptomics.British journal of cancer · 2026Article
- Article
- Tumor slice cultures enable rapid ex vivo profiling of patient-specific drug sensitivity in pancreatic ductal adenocarcinoma.NPJ precision oncology · 2026Article
- Biofabrication and artificial intelligence strategies for investigating solid- and fluid-pressure mechanobiology in pancreatic ductal adenocarcinoma.Cancer metastasis reviews · 2026Review
- Construction Strategies, Microenvironmental Modelling and Precision-Therapy Applications of Glioma Organoid Models.Cancers · 2026Review
- The role of gastric cancer patient-derived organoids in precision medicine: Clinicians' perspective.Stem cell reports · 2026Article
- Patient-derived organoids reveal ductal dysfunction and CFTR-modulator responses in chronic pancreatitis.Cell stem cell · 2026Article
632 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
70 authors at 20 institutions in 4 countries.
Hervé TiriacCold Spring Harbor Laboratory, Cold Spring Harbor, New York.
Pascal Belleau *Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.
Dannielle D Engle *Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.ORCID 0000-0003-1876-7675
Dennis PlenkerCold Spring Harbor Laboratory, Cold Spring Harbor, New York.ORCID 0000-0003-3895-4064
Astrid DeschênesCold Spring Harbor Laboratory, Cold Spring Harbor, New York.ORCID 0000-0001-7846-6749
Tim D D SomervilleCold Spring Harbor Laboratory, Cold Spring Harbor, New York.
Fieke E M FroelingCold Spring Harbor Laboratory, Cold Spring Harbor, New York.
Richard A BurkhartJohns Hopkins University, Division of Hepatobiliary and Pancreatic Surgery, Baltimore, Maryland.
Robert E DenrochePanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
Gun-Ho JangPanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
Koji MiyabayashiCold Spring Harbor Laboratory, Cold Spring Harbor, New York.
C Megan YoungCold Spring Harbor Laboratory, Cold Spring Harbor, New York.
Hardik PatelCold Spring Harbor Laboratory, Cold Spring Harbor, New York.
Michelle MaCold Spring Harbor Laboratory, Cold Spring Harbor, New York.
Joseph F LaCombDepartment of Medicine, Stony Brook University, Stony Brook, New York.
Randze Lerie D PalmairaMemorial Sloan Kettering Cancer Center, New York, New York.
Ammar A JavedJohns Hopkins University, Division of Hepatobiliary and Pancreatic Surgery, Baltimore, Maryland.
Jasmine C HuynhUniversity of California, Davis, Comprehensive Cancer Center, Division of Hematology and Oncology, Sacramento, California.
Molly JohnsonNew York Genome Center, New York, New York.
Kanika AroraNew York Genome Center, New York, New York.
Nicolas RobineNew York Genome Center, New York, New York.
Minita ShahNew York Genome Center, New York, New York.
Rashesh SanghviNew York Genome Center, New York, New York.
Austin B GoetzDepartment of Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania.
Cinthya Y LowderDepartment of Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania.
Laura MartelloSUNY Downstate Medical Center, Department of Medicine, New York, New York.
Else DriehuisHubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), Utrecht, the Netherlands.
Nicolas LeComteMemorial Sloan Kettering Cancer Center, New York, New York.
Gokce AskanMemorial Sloan Kettering Cancer Center, New York, New York.
Christine A Iacobuzio-DonahueMemorial Sloan Kettering Cancer Center, New York, New York.
Hans CleversHubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), Utrecht, the Netherlands.
Laura D WoodDepartment of Pathology, Johns Hopkins University, Baltimore, Maryland.
Ralph H HrubanDepartment of Pathology, Johns Hopkins University, Baltimore, Maryland.
Elizabeth ThompsonDepartment of Pathology, Johns Hopkins University, Baltimore, Maryland.
Andrew J AguirreDana-Farber Cancer Institute, Broad Institute, Boston, Massachusetts.
Brian M WolpinDana-Farber Cancer Institute, Broad Institute, Boston, Massachusetts.
Aaron SassonDepartment of Surgery, Stony Brook University, Stony Brook, New York.
Joseph KimDepartment of Surgery, Stony Brook University, Stony Brook, New York.
Maoxin WuDepartment of Pathology, Stony Brook University, Stony Brook, New York.
Juan Carlos BucoboDepartment of Medicine, Stony Brook University, Stony Brook, New York.
Peter AllenMemorial Sloan Kettering Cancer Center, New York, New York.
Divyesh V SejpalDonald and Barbara Zucker School of Medicine at Hofstra/Northwell, Division of Gastroenterology, Hempstead, New York.
William NealonDepartment of Surgery, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York.
James D SullivanDepartment of Surgery, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York.
Jordan M WinterDepartment of Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania.
Phyllis A GimottyDepartment of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania.
Jean L GremDepartment of Medicine, University of Nebraska Medical Center, Omaha, Nebraska.
Dominick J DiMaioDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska.
Jonathan M BuscagliaDepartment of Medicine, Stony Brook University, Stony Brook, New York.
Paul M GrandgenettUniversity of Nebraska Medical Center, Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffet Cancer Center, Omaha, Nebraska.
Jonathan R BrodyDepartment of Surgery, Thomas Jefferson University, Philadelphia, Pennsylvania.
Michael A HollingsworthUniversity of Nebraska Medical Center, Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffet Cancer Center, Omaha, Nebraska.
Grainne M O'KaneWallace McCain Centre for Pancreatic Cancer, Department of Medical Oncology, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Faiyaz NottaPanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
Edward KimUniversity of California, Davis, Comprehensive Cancer Center, Division of Hematology and Oncology, Sacramento, California.
James M CrawfordDepartment of Pathology and Laboratory Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York.
Craig DevoeDivision of Medical Oncology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York.
Allyson OceanWeill Cornell Medical College, New York, New York.
Christopher L WolfgangJohns Hopkins University, Division of Hepatobiliary and Pancreatic Surgery, Baltimore, Maryland.
Kenneth H YuMemorial Sloan Kettering Cancer Center, New York, New York.
Ellen LiDepartment of Medicine, Stony Brook University, Stony Brook, New York.
Christopher R VakocCold Spring Harbor Laboratory, Cold Spring Harbor, New York.
Benjamin HubertNew York Genome Center, New York, New York.
Sandra E FischerDepartment of Pathology, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Julie M WilsonPanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, Ontario, Canada.
Richard MoffittDepartment of Surgery, Stony Brook University, Stony Brook, New York.
Jennifer KnoxWallace McCain Centre for Pancreatic Cancer, Department of Medical Oncology, Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Alexander KrasnitzCold Spring Harbor Laboratory, Cold Spring Harbor, New York.
Steven GallingerPanCuRx Translational Research Initiative, Ontario Institute for Cancer Research, Toronto, Ontario, Canada. dtuveson@cshl.edu steven.gallinger@uhn.ca.
David A TuvesonCold Spring Harbor Laboratory, Cold Spring Harbor, New York. dtuveson@cshl.edu steven.gallinger@uhn.ca.
Cold Spring Harbor Laboratory · USStony Brook University · USKettering University · USNew York Genome Center · USOntario Institute for Cancer Research · CADonald & Barbara Zucker School of Medicine at Hofstra/Northwell · USThomas Jefferson University · USJohns Hopkins University · USNebraska Medical Center · USUniversity of Baltimore · USDana-Farber Cancer Institute · USPrincess Margaret Cancer Centre · CARoyal Netherlands Academy of Arts and Sciences · NLUniversity of California Davis Medical Center · USCornell University · USHofstra University · USSUNY Downstate Health Sciences University · USUniversity Health Network · CAUniversity of Nebraska Medical Center · USUniversity of Pennsylvania · US
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4MSingle-Cell Biology Shared ResourceP30CA045508 · NCI · COLD SPRING HARBOR LABORATORY · PI John Edward Moses · 1987 to 2026
$118.9MVIRAL TRANSACTIVATIONP01CA013106 · NCI · COLD SPRING HARBOR LABORATORY · PI William Richard McCombie · 1985 to 2026
$116.8MHarvard Clinical and Translational Science CenterUL1TR001102 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$106.2MTissue CoreP50CA127297 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI HOLLINGSWORTH, MICHAEL A. · 2008 to 2018
$17.1MPancreatic Cancer Detection ConsortiumU01CA210240 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Michael A. Hollingsworth · 2017 to 2026
$12.9MUAB / UMN SPORE in Pancreatic CancerP50CA101955 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BUCHSBAUM, DONALD J · 2010 to 2014
$11.1MCOMPUTATIONAL AND FUNCTIONAL APPROACHES TO VALIDATING CANCER GENOME TARGETSU01CA168409 · NCI · COLD SPRING HARBOR LABORATORY · PI POWERS, SCOTT · 2012 to 2016
$7.3MCSHL-JAX Patient-Derived Models of Pancreatic Cancer as Systems for Investigating Tumor HeterogeneityU01CA224013 · NCI · COLD SPRING HARBOR LABORATORY · PI ROBSON, PAUL, TUVESON, DAVID A · 2018 to 2022
$4.2MNrf2 Regulation of Ductal Pancreatic Cancer Etiology and Treatment ResponseR01CA188134 · NCI · COLD SPRING HARBOR LABORATORY · PI TUVESON, DAVID A · 2017 to 2021
$3.0MPharmacogenomic and circulating tumor cell approach to individualized treatment of pancreatic cancerR01CA202762 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI MCCARTHY, BRIAN J., YU, KENNETH H. · 2016 to 2020
$2.8M(PQA-4) Organoid Omics To Detect And Defeat Ductal Pancreatic CancerR01CA190092 · NCI · COLD SPRING HARBOR LABORATORY · PI TUVESON, DAVID A · 2014 to 2017
$2.2MNCATS NIH HHS UL1 TR001102NCI NIH HHS K08 CA218420NCI NIH HHS K99 CA204725NCI NIH HHS P01 CA013106NCI NIH HHS P20 CA192994NCI NIH HHS P20 CA192996NCI NIH HHS P30 CA008748NCI NIH HHS P30 CA045508NCI NIH HHS P50 CA101955NCI NIH HHS P50 CA127297NCI NIH HHS R01 CA101973NCI NIH HHS R01 CA188134NCI NIH HHS R01 CA190092NCI NIH HHS R01 CA202762NCI NIH HHS R01 CA212600NCI NIH HHS R50 CA211462NCI NIH HHS T32 CA148056NCI NIH HHS U01 CA168409NCI NIH HHS U01 CA210240NCI NIH HHS U01 CA224013NCI NIH HHS U10 CA180944
Abstract
Pancreatic cancer is the most lethal common solid malignancy. Systemic therapies are often ineffective, and predictive biomarkers to guide treatment are urgently needed. We generated a pancreatic cancer patient-derived organoid (PDO) library that recapitulates the mutational spectrum and transcriptional subtypes of primary pancreatic cancer. New driver oncogenes were nominated and transcriptomic analyses revealed unique clusters. PDOs exhibited heterogeneous responses to standard-of-care chemotherapeutics and investigational agents. In a case study manner, we found that PDO therapeutic profiles paralleled patient outcomes and that PDOs enabled longitudinal assessment of chemosensitivity and evaluation of synchronous metastases. We derived organoid-based gene expression signatures of chemosensitivity that predicted improved responses for many patients to chemotherapy in both the adjuvant and advanced disease settings. Finally, we nominated alternative treatment strategies for chemorefractory PDOs using targeted agent therapeutic profiling. We propose that combined molecular and therapeutic profiling of PDOs may predict clinical response and enable prospective therapeutic selection.
Indexed as
Antineoplastic AgentsDrug Resistance, NeoplasmDrug Screening Assays, AntitumorGene Expression ProfilingGene Expression Regulation, NeoplasticGene Regulatory NetworksHumansMolecular Targeted TherapyOrganoidsPancreatic NeoplasmsPrecision MedicineProspective StudiesSequence Analysis, RNAStandard of CareTumor Cells, CulturedAntineoplastic Agents
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Read underepoch 390
Registered trials
NCT05189171ClinicalTrials.gov
NCT05196334ClinicalTrials.gov
NCT05351983ClinicalTrials.gov
NCT05955092ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.