Evidence map›Paper›PMID 29853630›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018

Laminin β2 Chain Regulates Retinal Progenitor Cell Mitotic Spindle Orientation via Dystroglycan.

Dmitri Serjanov, Galina Bachay, Dale D Hunter, William J Brunken

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
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  7. Review
  8. Article
  9. Laminin β2 Chain Regulates Cell Cycle Dynamics in the Developing Retina.Frontiers in cell and developmental biology · 2021
    Article
  10. Article
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Dmitri SerjanovDepartment of Ophthalmology, Upstate Medical University, Syracuse, New York 13210.
Galina BachayDepartment of Ophthalmology, Upstate Medical University, Syracuse, New York 13210.
Dale D HunterDepartment of Ophthalmology, Upstate Medical University, Syracuse, New York 13210.ORCID 0000-0002-5619-8023
William J BrunkenDepartment of Ophthalmology, Upstate Medical University, Syracuse, New York 13210 brunkenw@upstate.edu.ORCID 0000-0001-7330-1814
SUNY Upstate Medical University · US

Funding

Role of Extracellular Matrix in Retinal Development and DiseaseR01EY012676 · NEI · UPSTATE MEDICAL UNIVERSITY · PI BRUNKEN, WILLIAM J · 2000 to 2021
$6.9M
NEI NIH HHS R01 EY012676
6 · The paper itself

Abstract

Vertebrate retinal development follows a pattern during which retinal progenitor cells (RPCs) give rise to all retinal cell types in a highly conserved temporal sequence. RPC proliferation and cell cycle exit are tightly coordinated to ensure proper and timely production of each of the retinal cell types. Extracellular matrix (ECM) plays an important role in eye development, influencing RPC proliferation and differentiation. In this study, we demonstrate that laminins, key ECM components, in the inner limiting membrane, control mitotic spindle orientation by providing environmental cues to the RPCs.

Indexed as

AnimalsCell PolarityDystroglycansExtracellular MatrixFemaleLamininMaleMiceMice, Inbred C57BLMice, KnockoutNeural Stem CellsNeurogenesisRetinal NeuronsSpindle ApparatusDystroglycansLamininlaminin beta2extracellular matrixmitotic spindleneurogenesisretinal development

Identifiers

PMID29853630
PMCPMC6021997
OpenAlexW2805795009

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.