Evidence map›Paper›PMID 29853627›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2018

Chemogenetic Activation of Prefrontal Cortex Rescues Synaptic and Behavioral Deficits in a Mouse Model of 16p11.2 Deletion Syndrome.

Wei Wang, Benjamin Rein, Freddy Zhang, Tao Tan, Ping Zhong, Luye Qin, Zhen Yan

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 70 citations in OpenAlex.

  1. Overview of the DREADDs chemogenetics and the patent landscape of their actuators.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
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  5. Sphingolipids in Emotional Well-Being.Journal of neurochemistry · 2026
    Review
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  12. Review
  13. Prefrontal cortical circuits in social behaviors: an overview.Journal of Zhejiang University. Science. B · 2024
    Review
  14. Article
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Wei WangDepartment of Physiology and Biophysics, State University of New York at Buffalo, Jacobs School of Medicine and Biomedical Sciences, Buffalo, New York 14214.
Benjamin ReinDepartment of Physiology and Biophysics, State University of New York at Buffalo, Jacobs School of Medicine and Biomedical Sciences, Buffalo, New York 14214.ORCID 0000-0002-9202-4469
Freddy ZhangDepartment of Physiology and Biophysics, State University of New York at Buffalo, Jacobs School of Medicine and Biomedical Sciences, Buffalo, New York 14214.ORCID 0000-0001-6769-8130
Tao TanDepartment of Physiology and Biophysics, State University of New York at Buffalo, Jacobs School of Medicine and Biomedical Sciences, Buffalo, New York 14214.ORCID 0000-0002-4571-3296
Ping ZhongDepartment of Physiology and Biophysics, State University of New York at Buffalo, Jacobs School of Medicine and Biomedical Sciences, Buffalo, New York 14214.
Luye QinDepartment of Physiology and Biophysics, State University of New York at Buffalo, Jacobs School of Medicine and Biomedical Sciences, Buffalo, New York 14214.
Zhen YanDepartment of Physiology and Biophysics, State University of New York at Buffalo, Jacobs School of Medicine and Biomedical Sciences, Buffalo, New York 14214 zhenyan@buffalo.edu.ORCID 0000-0002-3519-9596
University at Buffalo, State University of New York · US

Funding

Physiological and Pathophysiological Basis of StressR01MH108842 · NIMH · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI YAN, ZHEN · 2015 to 2019
$2.0M
Functions of D4 Dopamine Receptors in Prefrontal CortexR01DA037618 · NIDA · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI YAN, ZHEN · 2014 to 2018
$1.7M
Discovery of Novel Drugs for AutismR41MH112237 · NIMH · ASDDR, LLC · PI YAN, ZHEN · 2017 to 2018
$771k
NIDA NIH HHS R01 DA037618NIMH NIH HHS R01 MH108842NIMH NIH HHS R41 MH112237
6 · The paper itself

Abstract

Microdeletion of the human 16p11.2 gene locus has been linked to autism spectrum disorder (ASD) and intellectual disability and confers risk for a number of other neurodevelopmental deficits. Transgenic mice carrying 16p11.2 deletion (

Indexed as

AnimalsAutistic DisorderBehavior, AnimalChromosome DeletionChromosome DisordersChromosomes, Human, Pair 16Disease Models, AnimalFemaleIntellectual DisabilityMaleMiceMice, TransgenicPrefrontal CortexPyramidal CellsReceptors, N-Methyl-D-AspartateReceptors, N-Methyl-D-Aspartate16p11.2 deletionautism spectrum disorderDREADDNMDAprefrontal cortex

Identifiers

PMID29853627
PMCPMC6021990
OpenAlexW2806466487

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.