Evidence map›Paper›PMID 29853565›Full record

ArticleArteriosclerosis, thrombosis, and vascular biology2018

Naturally Occurring Variants in LRP1 (Low-Density Lipoprotein Receptor-Related Protein 1) Affect HDL (High-Density Lipoprotein) Metabolism Through ABCA1 (ATP-Binding Cassette A1) and SR-B1 (Scavenger Receptor Class B Type 1) in Humans.

Federico Oldoni, Julian C van Capelleveen, Nawar Dalila, Justina C Wolters, Joerg Heeren, Richard J Sinke, David Y Hui, Geesje M Dallinga-Thie, Ruth Frikke-Schmidt, Kees G Hovingh and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arteriosclerosis, thrombosis, and vascular biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Annual Report on Sex in Preclinical Studies:Arteriosclerosis, thrombosis, and vascular biology · 2020
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Federico OldoniFrom the Department of Pediatrics, Section of Molecular Genetics, University Medical Centre Groningen, University of Groningen, The Netherlands (F.O., J.C.W., B.v.d.S., J.A.K.).
Julian C van CapelleveenDepartment of Vascular Medicine (J.C.v.C., G.M.D.-T., K.G.H.).
Nawar DalilaDepartment of Clinical Biochemistry, Rigshospitalet (N.D., R.F.-S., A.T.-H.).
Justina C WoltersFrom the Department of Pediatrics, Section of Molecular Genetics, University Medical Centre Groningen, University of Groningen, The Netherlands (F.O., J.C.W., B.v.d.S., J.A.K.).
Joerg HeerenDepartment of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Germany (J.H.).
Richard J SinkeDepartment of Genetics, University Medical Centre Groningen, The Netherlands (R.J.S.).
David Y HuiDepartment of Pathology and Laboratory Medicine, Metabolic Diseases Institute, University of Cincinnati College of Medicine, OH (D.Y.H.).
Geesje M Dallinga-ThieDepartment of Vascular Medicine (J.C.v.C., G.M.D.-T., K.G.H.).
Ruth Frikke-SchmidtDepartment of Clinical Biochemistry, Rigshospitalet (N.D., R.F.-S., A.T.-H.).
Kees G HovinghDepartment of Vascular Medicine (J.C.v.C., G.M.D.-T., K.G.H.).
Bart van de SluisFrom the Department of Pediatrics, Section of Molecular Genetics, University Medical Centre Groningen, University of Groningen, The Netherlands (F.O., J.C.W., B.v.d.S., J.A.K.).
Anne Tybjærg-HansenDepartment of Clinical Biochemistry, Rigshospitalet (N.D., R.F.-S., A.T.-H.).
Jan Albert KuivenhovenFrom the Department of Pediatrics, Section of Molecular Genetics, University Medical Centre Groningen, University of Groningen, The Netherlands (F.O., J.C.W., B.v.d.S., J.A.K.) j.a.kuivenhoven@umcg.nl.
University Medical Center Groningen · NLAcademic Medical Center · NLFrederiksberg Hospital · DKUniversität Hamburg · DE

Funding

Role of Lipoprotein Receptors in Diet-induced Obesity and DiabetesR01DK074932 · NIDDK · UNIVERSITY OF CINCINNATI · PI HUI, DAVID YIU-KWAN · 2007 to 2019
$4.4M
NIDDK NIH HHS R01 DK074932
6 · The paper itself

Abstract

objectiveStudies into the role of LRP1 (low-density lipoprotein receptor-related protein 1) in human lipid metabolism are scarce. Although it is known that a common variant in APPROACH AND

resultsIn 2 subjects with HDL-C below the first percentile for age and sex and moderately elevated triglycerides, we identified 2 rare variants in

conclusionsThis study provides the first evidence that rare variants in

Indexed as

Genetic VariationApolipoprotein A-IATP Binding Cassette Transporter 1Cell Line, TumorCell MembraneCholesterol, HDLFibroblastsGenetic Predisposition to DiseaseHEK293 CellsHumansHypoalphalipoproteinemiasLiverLow Density Lipoprotein Receptor-Related Protein-1PhenotypeProspective StudiesProtein StabilityABCA1 protein, humanAPOA1 protein, humanApolipoprotein A-IATP Binding Cassette Transporter 1Cholesterol, HDLLow Density Lipoprotein Receptor-Related Protein-1LRP1 protein, humanSCARB1 protein, humanScavenger Receptors, Class BTriglyceridesapolipoproteincell membraneHDL cholesterollipid metabolismlow-density lipoprotein receptor–related protein 1triglycerides

Identifiers

PMID29853565
PMCPMC6023722
OpenAlexW2805769999

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.