Evidence map›Paper›PMID 29853471›Full record

ArticleDrug metabolism and disposition: the biological fate of chemicals2018

Age-Related Changes in Expression and Activity of Human Hepatic Mitochondrial Glutathione Transferase Zeta1.

Guo Zhong, Margaret O James, Marci G Smeltz, Stephan C Jahn, Taimour Langaee, Pippa Simpson, Peter W Stacpoole

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug metabolism and disposition: the biological fate of chemicals, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Age-Related Changes in miRNA Expression Influence GSTZ1 and Other Drug Metabolizing Enzymes.Drug metabolism and disposition: the biological fate of chemicals · 2020
    Article
  5. Pharmacokinetic and Biochemical Profiling of Sodium Dichloroacetate in Pregnant Ewes and Fetuses.Drug metabolism and disposition: the biological fate of chemicals · 2020
    Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Guo ZhongDepartment of Medicinal Chemistry (G.Z., M.O.J., M.G.S., S.C.J.), Department of Pharmacotherapy and Translational Research (T.L.), Center for Pharmacogenomics (T.L.), and Departments of Medicine and Biochemistry and Molecular Biology (P.W.S.), University of Florida, Gainesville, Florida; and Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin (P.S.).
Margaret O JamesDepartment of Medicinal Chemistry (G.Z., M.O.J., M.G.S., S.C.J.), Department of Pharmacotherapy and Translational Research (T.L.), Center for Pharmacogenomics (T.L.), and Departments of Medicine and Biochemistry and Molecular Biology (P.W.S.), University of Florida, Gainesville, Florida; and Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin (P.S.) mojames@ufl.edu.
Marci G SmeltzDepartment of Medicinal Chemistry (G.Z., M.O.J., M.G.S., S.C.J.), Department of Pharmacotherapy and Translational Research (T.L.), Center for Pharmacogenomics (T.L.), and Departments of Medicine and Biochemistry and Molecular Biology (P.W.S.), University of Florida, Gainesville, Florida; and Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin (P.S.).
Stephan C JahnDepartment of Medicinal Chemistry (G.Z., M.O.J., M.G.S., S.C.J.), Department of Pharmacotherapy and Translational Research (T.L.), Center for Pharmacogenomics (T.L.), and Departments of Medicine and Biochemistry and Molecular Biology (P.W.S.), University of Florida, Gainesville, Florida; and Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin (P.S.).
Taimour LangaeeDepartment of Medicinal Chemistry (G.Z., M.O.J., M.G.S., S.C.J.), Department of Pharmacotherapy and Translational Research (T.L.), Center for Pharmacogenomics (T.L.), and Departments of Medicine and Biochemistry and Molecular Biology (P.W.S.), University of Florida, Gainesville, Florida; and Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin (P.S.).
Pippa SimpsonDepartment of Medicinal Chemistry (G.Z., M.O.J., M.G.S., S.C.J.), Department of Pharmacotherapy and Translational Research (T.L.), Center for Pharmacogenomics (T.L.), and Departments of Medicine and Biochemistry and Molecular Biology (P.W.S.), University of Florida, Gainesville, Florida; and Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin (P.S.).
Peter W StacpooleDepartment of Medicinal Chemistry (G.Z., M.O.J., M.G.S., S.C.J.), Department of Pharmacotherapy and Translational Research (T.L.), Center for Pharmacogenomics (T.L.), and Departments of Medicine and Biochemistry and Molecular Biology (P.W.S.), University of Florida, Gainesville, Florida; and Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin (P.S.).
Medical College of Wisconsin · USUniversity of Florida · US

Funding

Using social networks to map and evaluate team science across CTSA hubsUL1TR001427 · NCATS · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A. · 2015 to 2024
$37.2M
UF Clinical and Translational Science AwardUL1TR000064 · NCATS · UNIVERSITY OF FLORIDA · PI NELSON, DAVID R · 2012 to 2014
$12.2M
Diversity Supplement to 2RO1 GM 099871R01GM099871 · NIGMS · UNIVERSITY OF FLORIDA · PI JAMES, MARGARET OLIVE, STACPOOLE, PETER WALLACE · 2012 to 2019
$2.7M
NCATS NIH HHS UL1 TR000064NCATS NIH HHS UL1 TR001427NIGMS NIH HHS R01 GM099871
6 · The paper itself

Abstract

Glutathione transferase zeta1 (GSTZ1) catalyzes glutathione (GSH)-dependent dechlorination of dichloroacetate (DCA), an investigational drug with therapeutic potential in metabolic disorders and cancer. GSTZ1 is expressed in both hepatic cytosol and mitochondria. Here, we examined the ontogeny and characterized the properties of human mitochondrial GSTZ1. GSTZ1 expression and activity with DCA were determined in 103 human hepatic mitochondrial samples prepared from livers of donors aged 1 day to 84 years. DNA from each sample was genotyped for three common GSTZ1 functional single nucleotide polymorphisms. Expression of mitochondrial GSTZ1 protein increased in an age-dependent manner to a plateau after age 21 years. Activity with DCA correlated with expression, after taking into account the somewhat higher activity of samples that were homo- or heterozygous for GSTZ1A. In samples from livers with the GSTZ1C variant, apparent enzyme kinetic constants for DCA and GSH were similar for mitochondria and cytosol after correcting for the loss of GSH observed in mitochondrial incubations. In the presence of 38 mM chloride, mitochondrial GSTZ1 exhibited shorter half-lives of inactivation compared with the cytosolic enzyme (

Indexed as

AdolescentAdultAgedAged, 80 and overAmino Acid SequenceChildChild, PreschoolCytosolDichloroacetic AcidDrugs, InvestigationalFemaleGlutathione TransferaseHumansInfantKineticsLiverDichloroacetic AcidDrugs, InvestigationalGlutathione TransferaseGSTZ1 protein, human

Identifiers

PMID29853471
PMCPMC6038028
OpenAlexW2807646507

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.